2008 Barriers of the CNS Gordon Research Conference

描述（由申请人提供）：本提案要求部分支持将于2008年6月22日至27日在新罕布什尔州蒂尔顿举行的关于中枢神经系统障碍的国际会议。本次会议的广泛和长期目标是增加我们对健康和疾病中与血脑屏障(BBB)/神经血管单元（NVU）相关的基本机制的理解。这次会议的主要目标之一是了解为什么血脑屏障会阻止重要的治疗药物进入患有中枢神经系统疾病的人的大脑。中枢神经系统疾病状态的问题以及血脑屏障/NVU在这些疾病状态中的作用是我们会议的中心主题。关于中枢神经系统障碍的戈登研究会议（GRC）是独一无二的，因为它将临床和基础科学研究（平等地）汇集在一起，在对患者重要的主题上进行充分和诚实的交流。由于我们缺乏对BBB/NVU的知识，我们共同努力解决无法治疗中枢神经系统疾病状态的长期问题，这对我们双方都有利。本次会议的具体目标是召集45位演讲者，介绍基础和临床疾病研究的关键领域，共有150名参与者，在新罕布什尔州蒂尔顿蒂尔顿学校的孤立和私人环境中举行为期五天的会议。该计划将有两个主题演讲和八个会议，广泛讨论当前的问题，包括血脑屏障紧密连接和屏障调节，血脑屏障转运蛋白和屏障功能，健康和疾病中的脉络丛/血- csf屏障，血脑屏障/NVU成像，视网膜，脊柱和肿瘤屏障，脑卒中中的血脑屏障/NVU，阿尔茨海默病中的血脑屏障/NVU，以及炎症中的血脑屏障/NVU。该应用的意义在于，CNS屏障GRC是CNS屏障领域提供的会议总数的一半。另外只提供一次会议，每隔一年向GRC提供一次。这个GRC是我们唯一的两年一次的会议。这次GRC会议推动了BBB/NVU研究人员的国际研究。此应用程序的运行状况相关性很清楚。讨论将确定用药物治疗中枢神经系统疾病状态的策略。在GRC上的讨论将描绘如何理解中枢神经系统疾病状态和BBB/NVU的未来，并讨论为什么迄今为止许多中枢神经系统治疗不成功。公共卫生相关性：该应用程序与健康的相关性是明确的。讨论将确定用药物治疗中枢神经系统疾病状态的策略。在GRC上的讨论将描绘如何理解中枢神经系统疾病状态和BBB/NVU的未来，并讨论为什么迄今为止许多中枢神经系统治疗不成功。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting to be held on Barriers of the Central Nervous System (CNS) in Tilton, New Hampshire on June 22 to 27, 2008. The broad and long term goal of this conference is to increase our understanding of the fundamental mechanisms associated with the blood brain barrier (BBB)/neurovascular unit (NVU) in health and disease. One of the primary goals of this meeting is to understand why the BBB excludes important therapeutics from entering the brain of people afflicted with diseases of the CNS. The issue of CNS disease states and the role the BBB/NVU plays in these disease states is the central theme of our meeting. The Gordon Research Conference (GRC) on Barriers of the CNS is unique because it brings together (equally) both clinical and basic science researches in a format where full and honest exchange occurs on subjects important to the patient. It is to our mutual benefit that we work together to solve the long term problem associated with an inability to treat CNS disease states because of our paucity of knowledge about the BBB/NVU. The Specific Aims of this meeting will be to convene 45 speakers that present critical areas of both basic and clinical disease research with a total of 150 participants for a five day conference in the isolated and private setting of Tilton School, Tilton, New Hampshire. The program will have two keynote addresses and eight sessions that broadly address current issues in BBB Tight Junctions and Barrier Regulation, BBB Transporters and Barrier Functions, Choroid plexus/Blood-CSF Barrier in health and disease, BBB/NVU imaging, retinal-, spinal-, and tumor barriers, BBB/NVU in stroke, BBB/NVU in Alzheimer's disease, and the BBB/NVU in inflammation. The significance of this application is that the GRC on Barriers of the CNS is one half of the total number of conferences offered in the area of Barriers of the CNS. Only one other conference is offered and it is offered in alternate years to the GRC. This GRC is our only conference every two years. This GRC conference propels research in the international community of BBB/NVU researchers. The health relatedness of this application is clear. Discussions will define strategies to treat CNS disease states with drugs. Discussions at GRC will map the future for defining how to understand CNS disease states and the BBB/NVU and discuss why many CNS therapeutics have been unsuccessful to date. PUBLIC HEALTH RELEVANCE: The health relatedness of this application is clear. Discussions will define strategies to treat CNS disease states with drugs. Discussions at GRC will map the future for defining how to understand CNS disease states and the BBB/NVU and discuss why many CNS therapeutics have been unsuccessful to date.