Sdl: a model for lymphocytic leukemia

描述(由申请人提供)： 我们通过研究自发性显性白血病(SDL)小鼠突变来阐明白血病形成的遗传基础。SDL突变出现在我们殖民地的一名雄性育种者的种系中，并导致继承该突变的小鼠在生命早期出现高穿透性淋巴细胞白血病。在这个模型中，生殖系遗传和疾病外显率接近100%，这提供了一个独特的情况，可以分析这些小鼠的造血系统中的肿瘤前状态。在SDL小鼠体内，细胞的早期分子变化可以作为人类早期疾病存在的生物标记物。我们假设，研究SDL小鼠将识别与淋巴细胞白血病启动和进展有关的遗传事件，并可能识别新的人类白血病癌基因。

DESCRIPTION (provided by applicant): We are elucidating the genetic basis of leukemia formation by studying the Spontaneous dominant leukemia (Sdl) mouse mutant. The Sdl mutation arose in the germline of a male breeder in our colony, and results in highly penetrant lymphocytic leukemia early in life in mice that inherit the mutation. The germline inheritance combined with disease penetrance approaching 100% in this model provides a unique situation that allows the pre-neoplastic state in the hematopoietic system of these mice to be analyzed. Early molecular changes in cells that will undergo transformation in Sdl mice could serve as biomarkers for the presence of early disease in humans. We hypothesize that studying the Sdl mouse will identify genetic events involved in lymphocytic leukemia initiation and progression and will potentially identify a new human leukemia oncogene.