Nanoparticles and Nanocapsules for Glioma Targeting

描述(由申请人提供)：LNK ChemSolutions LLC与芝加哥大学的研究人员合作开发纳米胶囊技术，以增强对胶质瘤的输送。初步结果特别令人鼓舞，因为纳米胶囊在健康的大鼠大脑中表现出非常好的运输能力，而且它们可以很容易地设计成用于靶向递送和定时有效载荷释放。体外和体内模型旨在确定这些纳米胶囊穿透血脑屏障和治疗诱发肿瘤的能力。该团队已经测试了各种成像技术和纳米胶囊表征方法，并取得了很好的成功。从商业角度来看，该技术平台是通用和灵活的，从长远来看，将允许该公司开发药物输送平台产品线。 公共卫生相关性：描述了一种设计纳米颗粒和纳米胶囊以增强胶质瘤靶向性的新策略。来自医学、化学和化学工程领域的科学家参与了这一多管齐下的方法。从商业角度来看，与其他方法相比，制造的简易性和封装的成品率被视为该技术的关键竞争特征。

DESCRIPTION (provided by applicant): LNK Chemsolutions LLC collaborates with researchers from the University of Chicago to develop nanocapsule technology for enhanced delivery to gliomas. Preliminary results are particularly encouraging in that the nanocapsules display very good transport in healthy rat brains, and they can easily be designed for targeted delivery and timed payload release. In vitro and in vivo models aimed at determining the ability of these nanocapsules to penetrate the blood brain barrier and to treat induced tumors are envisioned. A variety of imaging techniques and nanocapsule characterization methods have already been tested by the team with very good success. From a commercial standpoint, the technology platform is general and flexible, and will allow the company to develop a drug delivery platform product line in the long term. Public Health Relevance: A novel strategy to design nanoparticles and nanocapsules that enhance targeting of gliomas is described. The multi-pronged approach involves scientists from the medical, chemistry and chemical engineering fields. From a commercial standpoint, ease of fabrication and encapsulation yields are viewed as key competitive traits of the technology in this proposal compared to alternative methods.