Novel Acrylic Bone Cement Using Surface Functionalized Nanoparticles

项目描述（由申请人提供）：本项目将开发新型表面功能化纳米颗粒作为丙烯酸骨水泥材料，该材料具有高透明度、易于处理、生物活性和低放热。这种材料目前还没有，将为骨科医生和他们的患者提供更耐用、更有生物活性的植入材料，并提高诊断能力。第一阶段计划的第一个目标是探索开发合成表面功能化BaSO4和ZrO2纳米颗粒作为丙烯酸骨水泥放射性不透明剂的通用方法的可行性。我们预计，表面功能化可以使纳米级颗粒在甲基丙烯酸酯单体中容易均匀分散。这个第一阶段SBIR研究计划的第二个主要目标是开发新型纳米骨水泥填充材料，这种材料表面功能化，但也具有生物活性和不透光性。我们建议合成层状材料，磷酸氢锆（Zr(HPO4)2.H2O）作为不透射线和控释纳米颗粒，可以调节Ca2+， Zn2+离子活性}，已知是诱导生物活性的重要金属。这个第一阶段项目的第三个目标是开发一系列测试来评估机械性能和体外生物分析，以评估新型纳米材料在丙烯酸骨水泥配方中的性能。与现有的丙烯酸骨水泥相比，本方案提出的新型骨水泥使用起来更容易，从而大大改善了目前手术室的工作流程。随着骨科植入物数量的显著增加（从1990年到2000年增加了33%）和接受植入物的患者预期寿命的延长，迫切需要提高这些手术中常用的骨水泥的性能。该提案的重点是开发比现有商业水泥具有生物活性、更强、更持久、更容易处理和更容易成像的优质骨水泥。这些改进是通过一种新型的纳米颗粒功能化工艺实现的，该工艺创造了多功能水泥填料，并使用了一种独特的层状离子交换材料，可以诱导生物活性。如果成功，随后的商业化将为越来越多的脊柱、髋关节和膝关节相关手术创造新一代骨水泥。

DESCRIPTION (provided by applicant): This Phase I project will develop novel surface functionalized nanoparticles as acrylic bone cement materials with high radiopacity, ease of handling, bioactive and less exothermic. Such materials are not available today and will provide orthopedic surgeons and their patients with more durable and bioactive implant materials with improved diagnostic capabilities. The first goal of this phase I program is to explore the feasibility of developing general methods for the synthesis of surface functionalized BaSO4 and ZrO2 nanoparticles as radiopacifying agents for acrylic bone cement. We anticipate that surface functionalization allows easy and homogeneous dispersion of the nano-sized particles in methacrylate monomers. A second primary goal of this phase I SBIR research program is to develop novel nano-sized bone cement fillers that are surface functionalized but are also bioactive and radiopaque. We propose the synthesis of the lamellar material, zirconium hydrogen phosphate (Zr(HPO4)2.H2O) as radiopaque and controlled-release nanoparticles that can regulate Ca2+, Zn2+ ion-activities} metals known to be important in inducing bioactivity. A third goal of this phase I program is to develop a series of tests to evaluate the mechanical properties and in vitro biological assays to assess the performance of novel nanomaterials in an acrylic bone cement formulation. Compared to existing acrylic bone cements, the novel bone cement proposed in this program would be much easier to use, thus significantly improve current workflow in an operating room. PUBLIC HEALTH REVELANCE With the significant increase in the number of orthopedic implants (33% increase from 1990 to 2000) and the increasing life expectancy of patients receiving implants, there is an urgent need to enhance the properties of bone cements that are commonly used in these procedures. This proposal is focused on developing superior bone cements that are bioactive, stronger, longer lasting, easier-to-handle and easier-to-image than existing commercial cements. These improvements are enabled by a novel nanoparticle functionalization process that creates multi-functional cement fillers and by the use of a unique lamellar ion-exchange material that can induce bioactivity. If successful, subsequent commercialization will create a new generation of bone cements for the growing numbers of spinal, hip and knee-related procedures.