NEUROSCIENCE CORE

内侧隔区和斜角带(内侧隔区)是基底前脑的一个部分，即 受衰老的影响，特别是受阿尔茨海默氏症的影响。内侧隔区包含一个 不同种类的神经元，包括胆碱能和非胆碱能投射神经元和 中间神经元。尽管隔区神经元群的输入是正常处理所必需的 通过海马体和新皮质网络的信息，只有关于解剖的零散信息， 大多数隔神经元的电生理学和药理学(胆碱能细胞是 例外)当前可用。此外，隔区神经元群的连通性及其 随着年龄的变化从根本上说是未知的。该提案致力于识别突触连接 在隔区神经元中，通过这些连接建立的功能回路和衰老对 隔突触连接。建议的实验将有助于正常和年龄改变的建模 间隔连通性。它们也可能导致致力于调节认知过程的治疗策略。 并减轻与年龄相关的疾病，特别是阿尔茨海默氏症的负担。实验性的 这项建议中描绘的战略还将为机构内和机构间提供强有力的机会 UTB/TSC教师的合作和新的职业发展机会。

The medial septum and diagonal bands (medial septal region) is a division of the basal forebrain that is affected by aging and in particular by Alzheimer's disease. The medial septal region contains a heterogeneous population of neurons, including cholinergic and non-cholinergic projection neurons and interneurons. Even though inputs from septal neuronal populations are necessary for the normal processing of information by hippocampal and neocortical networks, only fragmented information on the anatomy, electrophysiology and pharmacology of most septal neuronal populations (cholinergic cells are the exception) is currently available. In addition, the connectivity of septal neuronal populations and their alteration with aging is fundamentally unknown. This proposal is dedicated to identify synaptic connections among septal neurons, the functional circuits established through these connections and the aging effect on septal synaptic connectivity. The proposed experiments will facilitate the modeling of normal and age-altered septal connectivity. They also may result in therapeutic strategies dedicated to modulate cognitive processes and alleviate the burden of age-related disorders, in particular Alzheimer's disease. The experimental strategy delineated in this proposal will also provide strong opportunities for intra- and inter-institutional collaborations and new career development opportunities for UTB/TSC faculty.