Senselab: Integration of Multidisciplinary Sensory Data

描述(由申请人提供)：这笔赠款的主要目的是开发数据库和数据库工具，以支持实验神经科学。我们使用嗅觉通路作为模型系统，为其构建了一组链接的数据库，称为SenseLab。我们的项目利用了三个组成项目的专业知识。项目1将开发数据库并将其应用于嗅觉通路连续阶段的实验研究。这些数据库包括嗅觉受体数据库(ORDB)和NeuronDB，前者拥有超过5,000个化学感官受体的档案，后者存档了辅助树突整合的细胞膜属性。新的举措包括支持嗅觉受体基因表达的基因芯片分析的ORarrayDB，以及支持分析功能磁共振气味图谱并与各种活动图谱方法生成的图谱相关联的OdorMapDB。项目2隶属于耶鲁医学信息学中心，该中心提供神经信息学基础研究所需的专业知识，并将其应用于项目1和项目3的实验和数据库。它将扩展一个称为EAWCR的高度灵活的数据库结构，不仅可以增强我们的项目，还可以发起新的倡议，以提供人脑项目数据库(HBPDB)和更广泛的神经科学数据库(DBofNDB)之间的互操作性。项目3负责开发和维护神经元模型数据库(ModelDB)，主要基于软件工具神经元，这是神经元整合计算建模的领先程序。项目3将与项目1合作，对嗅觉神经元和微电路进行建模研究，并将在目前存档的100个模型之外继续开发ModelDB。该计划项目的结果应该提供一个模型，说明相互关联的数据库如何对模型系统的实验分析至关重要，并应该提供具有普遍适用性的工具，以促进数据库在整个神经科学中的使用。

DESCRIPTION (provided by applicant): The main aim of this grant is to develop databases and database tools in support of experimental neuroscience. We use as a model system the olfactory pathway, for which we have constructed a set of linked databases that is called SenseLab. Our project draws on expertise in three constituent projects. Project 1 will develop and apply the databases to experimental studies of successive stages in the olfactory pathway. These databases include Olfactory Receptor Database (ORDB) with an archive of over 5,000 chemical sensory receptors, and NeuronDB, which archives membrane properties that subserve dendritic integration. New initiatives include ORarrayDB to support genechip analysis of olfactory receptor gene expression, and OdorMapDB to support analysis of fMRI odor maps and correlation with maps generated by a variety of activity mapping methods. Project 2 is under the Yale Center for Medical Informatics, which provides the expertise needed for basic research in neuroinformatics and applications to the experiments and databases of Projects 1 and 3. It will expand a highly flexible database structure termed EAWCR not only to enhance our projects but also to launch new initiatives to provide for interoperability between Human Brain Project databases (HBPDB) and neuroscience databases more broadly (DBofNDB). Project 3 is responsible for development and maintenance of a database of neuronal models (ModelDB), primarily based on the software tool NEURON, a leading program for computational modeling of neuronal integration. Project 3 will collaborate with Project 1 on studies to model olfactory neurons and microcircuits, and will continue to develop ModelDB beyond the 100 models currently archived. The results of this program project should provide a model for how interlinked databases can be essential for experimental analysis of a model system, and should provide tools of general applicability to promote the use of databases throughout neuroscience.