CHARACTERIZATION OF ENGINEERED MOUSE MODELS OF OBESITY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 神经解剖学、神经药理学和遗传学研究已经确定了CNS神经元群在体重稳态调节中的关键作用。 为了评估这些CNS通路的功能意义，有必要以神经元特异性的方式“扰动”神经肽和/或其受体，然后评估对能量稳态的影响。 小鼠中的遗传方法，利用cre或flp介导的DNA重组（即，cre/LOX和flp/FRT技术），为此类研究提供了手段。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Neuroanatomical, neuropharmacological, and genetic studies have identified CNS neuronal groups that are critical in the regulation of body weight homeostasis. To assess the functional significance of these CNS pathways, it is necessary to "perturb" neuropeptides and/or their receptors, in a neuron-specific fashion, and then assess effects on energy homeostasis. Genetic approaches in mice, utilizing cre- or flp-mediated DNA recombination (i.e., cre/LOX and flp/FRT technology), provide the means for such studies.