IMMUNOBIOLOGY OF SAIDS-ASSOCIATED LYMPHOMAS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们正在继续我们与Laura Levy博士的合作项目，检查感染SIV和未感染SIV的恒河猴的淋巴瘤。到目前为止，我们已经确认了大量的猴艾滋病相关淋巴瘤(Sarl)病例，并正在比较年龄匹配的对照组动物的各种实验室和临床数据，包括存活时间、绝对和相对B细胞和T细胞计数、B细胞和T细胞在病程中的变化率、淋巴样增生的临床证据以及外周血液抗原血症。采用病例对照的方法对数据进行统计分析。最近完成了统计分析，并被证明是详尽的。结果产生了至少500页的输出，我们正在继续分析。我们还在通过免疫组织化学检测淋巴瘤组织中的细胞亚群。伊万娜·潘德雷亚博士现在也在与利维博士合作，通过各种技术来治疗淋巴瘤的表型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are continuing our collaborative project with Dr. Laura Levy in examining lymphomas in SIV-infected and uninfected rhesus macaques. To date, we have identified numerous cases of simian AIDS-related lymphoma (sARL) and are comparing age matched control animals for various laboratory and clinical data including survival time, absolute and relative B-cell and T-cell counts, rate of B-cell and T-cell change over the disease course, clinical evidence of lymphoid hyperplasia, and peripheral blood antigenemia. The data were than analyzed statistically in a case-control manner. The statistical analysis was recently completed, and proved to be exhaustive. At least 500 pages of output resulted, which we are continuing to analyze. We are also examining subsets of cells in lymphoma tissues by immunohistochemistry. Dr. Ivona Pandrea is also now working with Dr. Levy to phenotype lymphomas by various techniques.