Development Research Program
Development Research Program
批准号:
7567939
负责人:
STEPHEN B. BAYLIN
金额:
$38.04万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-10-01 至 2013-09-30
关键词:
AcuteAdenocarcinomaAdjuvantAdverse eventAerosolsAnimalsAwardAzacitidineBiological MarkersBloodBreathingCaliberCancer PatientCanis familiarisCharacteristicsDataDepositionDevelopmentDiseaseDrug FormulationsDrug KineticsEarly DiagnosisEventFosteringFoundationsFundingGene SilencingGenerationsGenesHalf-LifeHeadHistone Deacetylase InhibitorHumanHypermethylationKnowledgeLaboratoriesLiquid substanceLungMalignant neoplasm of lungMethodsMethylationModelingMyeloproliferative diseaseNebulizerNew MexicoParticle SizePathway interactionsPatientsPharmaceutical PreparationsPharmacologic SubstancePhase I Clinical TrialsPhase I/II TrialPilot ProjectsPropertyRattusRecurrenceReproduction sporesResearch InstituteResearch PersonnelResectedRodentRouteSignal PathwaySputumSquamous cell carcinomaStagingStructure of parenchyma of lungSubcutaneous InjectionsTechnologyTestingTherapeutic AgentsTimeToxicologyTranslatingTumor Suppressor GenesUnited States National Institutes of HealthUniversitiesWorkanticancer researchaqueouscancer therapycareerdemethylationefficacy testingin vivoinnovationinsightlymph nodesnanoparticlenonhuman primateprogramspromoterresearch and developmentrespiratorytumortumor growth
中文摘要
事实证明,我们孢子的发展基金部分是我们肺癌转化工作中最重要的方面之一。正如下面将详细描述的,在孢子持续期间,我们的几个最有成效的完整项目开始时是通过这个发展计划资助的试点项目。此外,该计划还使多个翻译研究人员的学术生涯的开始成为可能,他们现在是这个和其他孢子的关键参与者。它还将基础研究人员带到了肺癌研究中,他们可能从未研究过这些疾病。最后,正如下面对当前提案的三个计划项目的完整介绍所表明的那样,我们利用发展计划机制将创新的新概念和技术引入孢子,以促进我们的最高翻译目标。
英文摘要
The developmental funds portion of our SPORE has proven to be one of the most vital aspects of our translational work in lung cancer. As will be detailed below, over the duration of the SPORE, several of our most productive full projects began as pilot projects funded through this Developmental Program. Also, this program has made possible the initiation of academic careers for multiple translational investigators who are now key players in this and other SPORES. It has also brought basic investigators to lung cancer research who might not have ever worked on these diseases. Finally, as will be evident below in the full presentation of three planned projects for the current proposal, we have used the Developmental Program mechanism to bring innovative new concepts and technology into the SPORE to foster our highest translational aims.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Epigenetic Therapies - New Approaches
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批准号:10696160
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项目类别:
-
资助金额:$234.54万
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财政年份:2021
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负责人:STEPHEN B. BAYLIN
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依托单位:
Epigenetic Therapies - New Approaches
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批准号:10269639
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项目类别:
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资助金额:$226.97万
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财政年份:2021
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负责人:STEPHEN B. BAYLIN
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依托单位:
Epigenetic Therapies - New Approaches
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批准号:10470361
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项目类别:
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资助金额:$234.54万
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财政年份:2021
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负责人:STEPHEN B. BAYLIN
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依托单位:
Organoid modeling to determine and reverse age-related epigenetic changes contributing to risk of colorectal cancer
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批准号:10206053
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项目类别:
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资助金额:$24.08万
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财政年份:2019
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负责人:STEPHEN B. BAYLIN
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依托单位:
Characterizing age-associated epigenetic alterations and their roles in tumor development
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批准号:9926803
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项目类别:
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资助金额:$12.28万
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财政年份:2019
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负责人:STEPHEN B. BAYLIN
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依托单位:
Organoid modeling to determine and reverse age-related epigenetic changes contributing to risk of colorectal cancer
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批准号:10657739
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项目类别:
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资助金额:$40.72万
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财政年份:2019
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负责人:STEPHEN B. BAYLIN
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依托单位:
Organoid modeling to determine and reverse age-related epigenetic changes contributing to risk of colorectal cancer
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批准号:10457265
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项目类别:
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资助金额:$40.72万
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财政年份:2019
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负责人:STEPHEN B. BAYLIN
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依托单位:
(PQ4) - Tools for simultaneous disruption of multiple epigenetically silenced genes for studying their roles in tumorigenesis using ex vivo human and mouse colon organoid and in vivo mouse models
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批准号:10471240
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项目类别:
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资助金额:$36.71万
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财政年份:2018
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负责人:STEPHEN B. BAYLIN
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依托单位:
Epigenetic Drivers of Cancer (PQ 10)
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批准号:8538911
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项目类别:
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资助金额:$55.32万
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财政年份:2012
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负责人:STEPHEN B. BAYLIN
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依托单位:
Epigenetic Drivers of Cancer (PQ 10)
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批准号:9039821
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项目类别:
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资助金额:$69.81万
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财政年份:2012
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负责人:STEPHEN B. BAYLIN
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依托单位:
Epigenetic Drivers of Cancer (PQ 10)
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批准号:8384811
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项目类别:
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资助金额:$61.45万
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财政年份:2012
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负责人:STEPHEN B. BAYLIN
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依托单位:
Epigenetic Drivers of Cancer (PQ 10)
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批准号:8691388
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项目类别:
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资助金额:$57.18万
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财政年份:2012
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负责人:STEPHEN B. BAYLIN
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依托单位:
The USC-JHU Cancer Epigenome Characterization Center
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批准号:8323982
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项目类别:
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资助金额:$187.53万
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财政年份:2009
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负责人:STEPHEN B. BAYLIN
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依托单位:
The USC-JHU Cancer Epigenome Characterization Center
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批准号:9214434
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项目类别:
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资助金额:$41.7万
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财政年份:2009
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负责人:STEPHEN B. BAYLIN
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依托单位:
The USC-JHU Cancer Epigenome Characterization Center
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批准号:8117718
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项目类别:
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资助金额:$306.82万
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财政年份:2009
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负责人:STEPHEN B. BAYLIN
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依托单位:
The USC-JHU Cancer Epigenome Characterization Center
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批准号:8896924
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项目类别:
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资助金额:$24.96万
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财政年份:2009
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负责人:STEPHEN B. BAYLIN
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依托单位:
The USC-JHU Cancer Epigenome Characterization Center
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批准号:7789003
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项目类别:
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资助金额:$198.63万
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财政年份:2009
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负责人:STEPHEN B. BAYLIN
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依托单位:
The USC-JHU Cancer Epigenome Characterization Center
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批准号:8519366
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项目类别:
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资助金额:$229.98万
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财政年份:2009
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负责人:STEPHEN B. BAYLIN
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依托单位:
Cancer Genome Characterization Center at Johns Hopkins
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批准号:7910931
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项目类别:
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资助金额:$52.4万
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财政年份:2009
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负责人:STEPHEN B. BAYLIN
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依托单位:
The USC-JHU Cancer Epigenome Characterization Center
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批准号:8925191
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项目类别:
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资助金额:$49.89万
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财政年份:2009
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负责人:STEPHEN B. BAYLIN
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依托单位:
国内基金
海外基金
大肠癌发生机制的adenoma-adenocarcinoma pathway同serrated pathway的关系的研究
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批准号:30840003
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项目类别:专项基金项目
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资助金额:12.0万元
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批准年份:2008
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负责人:焦宇飞
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依托单位: