FUNCTIONAL DYNAMICS OF THE RIBOSOME DURING TRANSLATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 摘要 Joachim Frank的核糖体小组的一个项目专注于核糖体在翻译过程中的功能动力学。 Frank博士实验室的Xabier Agirrezabala博士正在与M <$ns Escherberg博士的小组（见项目C-1）合作，设计合适标本的实验。 该项目的底物数量非常少，这个问题阻碍了该项目的进展; Escherberg实验室正在努力合成荧光底物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ABSTRACT A project with Joachim Frank's ribosome group focuses on the functional dynamics of the ribosome during translation. Dr. Xabier Agirrezabala in Dr. Frank's lab is working with Dr. M¿ns Ehrenberg's group (see project C-1) for design of experiments with suitable specimens. The substrates for this project are available in very small amounts and this problem has hindered progress on this project; efforts to synthesize fluorescent substrates are underway in the Ehrenberg lab.