FAMILIAL PSYCHIATRIC DISORDERS & SCHIZOPHRENIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目是一项家庭遗传学研究，比较了儿童期发病的精神分裂症和注意力缺陷多动障碍。本研究的目的是确定与精神分裂症表型不同方面相关的基因。我们之前的工作证实了早先的报道，即儿童期首发精神分裂症是一种比成人首发精神分裂症更具家族性的形式，并通过比较三种精神分裂症表型补充指标的敏感度和特异度来帮助完善精神分裂症表型的特征：1)精神分裂症的诊断；2)临床访谈或问卷定义的精神分裂症谱系人格障碍的存在，以及3通过某些注意力/信息处理措施发现的神经认知障碍。神经认知测试是精神分裂症表型最敏感的指标，而精神分裂症的诊断是精神分裂症谱系障碍最特异的指标。此外，我们使用高分辨率SPGR图像采集协议收集了16名精神分裂症儿童和24名正常对照儿童的磁共振成像。我们分析了内侧颞叶体积(杏仁核和前后海马体)、总颞叶体积和总脑体积，以复制先前关于精神分裂症患者内侧颞叶结构显著减少的报道。我们将开始收集儿童发病先证者的兄弟姐妹的成像数据，以检查先前研究表明精神分裂症患者的结构体积比正常对照组更小或更大，与上面提到的精神分裂症表型的三种替代指标的存在之间的关系。此外，我们将尝试确定与精神分裂症先证者及其兄弟姐妹大脑中存在的形态计量学变化相关的基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is a family genetic study comparing childhood onset schizophrenia and attention deficit hyperactivity disorder. The objective of this study is to identify genes associated with different facets of the schizophrenia phenotype. Our prior work corroborated earlier reports that childhood onset schizophrenia is a more familial form of schizophrenia than adult onset schizophrenia and helped to refine the characterization of the schizophrenia phenotype by comparing the sensitivity and specificity of three complimentary measures of the schizophrenia phenotype: 1) a diagnosis of schizophrenia; 2) presence of schizophrenic spectrum personality disorders defined by clinical interview or by questionnaire, and 3 neurocognitive impairments tapped by certain measures of attention/information processing. The neurocognitive measures were the most sensitive index of the schizophrenia phenotype while a diagnosis of schizophrenia was the most specific index of schizophrenia spectrum disorders . In addition, we have collected MRIs from 16 schizophrenic children and 24 normal control children using a high resolution SPGR image acquisition protocol. We have analyzed mesial temporal lobe volumes (amygdala and anterior and posterior hippocampus), total temporal lobe volume and total brain volume in order to replicate prior reports of significant reduction in mesial temporal structures in schizophrenic patients. We will begin to collect imaging data for siblings of child onset probands to examine the relationship between the volume of structures demonstrated in prior research to be either smaller or larger in schizophrenic patients than normal controls, and the presence of the three alternative measures of the schizophrenia phenotype cited above. In addition, we will attempt to identify genes associated with the presence of morphometric changes in the brains of schizophrenic probands and their siblings.