STRUCTURAL AND FUNCTIONAL MAPPING OF PROGRESSIVE APHASIA

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 原发性进行性失语症（PPA）是一种由大脑语言相关区域神经元缺失或功能障碍引起的交际障碍。虽然患者最初表现为孤立的语言功能障碍，但这种障碍是渐进的，最终导致非交流状态。与症状突然发作的脑血管意外相反，其中病变几乎从不局限于语言网络，并且病变部位内的所有神经元件都被不加区别地破坏，PPA导致部分和进行性功能障碍，并最终丧失受影响区域内的特定神经元群体。 由此产生的临床图片的特点是症状的组合和分离很少看到其他形式的失语症。本课题组和其他研究者的研究已经证实了PPA的区域性退化变化。然而，随着时间的推移，这些变化的过程，它们扩散到附近的皮质区域，以及与功能和代谢变化的对应关系尚未得到检查。该计划项目资助的这一部分的主要目的是研究这些问题：将使用高分辨率磁共振成像和高维时空映射随时间跟踪PPA的灰色和白色物质的变化。这将与加州大学洛杉矶分校的神经成像实验室合作进行。这些变化与词汇处理的改变之间的关联将使用功能性磁共振成像进行检查。最后，将结合MRI图像和氟脱氧葡萄糖正电子发射断层扫描来研究解剖和代谢变化之间的对应关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary progressive aphasia (PPA) is a communicative disorder caused by the loss or dysfunction of neurons within language-related areas of the brain. Although patients initially present with isolated language dysfunction, the disorder is progressive and leads eventually to a non-communicative state. In contrast to cerebrovascular accidents where the onset of symptoms is abrupt, where the lesion is almost never confined just to the language network, and where all neural elements within the lesioned site are destroyed indiscriminately, PPA leads to a partial and progressive dysfunction and eventual loss of specific neuronal populations within affected areas. The resultant clinical picture is characterized by symptom combinations and dissociations rarely seen in other forms of aphasia. Previous studies from our group and others have demonstrated the regional involutional changes in PPA. However, course of these changes, their spread to nearby cortical regions, and the correspondence with functional and metabolic changes has not been examined over time. The primary aims of this component of the program project grant are to examine these issues: Changes in gray and white matter with PPA will be tracked over time using high resolution magnetic resonance imaging and high-dimensional spatiotemporal mapping. This will be performed in collaboration with the Laboratory of Neuro Imaging at UCLA. The association of these changes with alterations in lexical processing will be examined using functional magnetic resonance imaging. Finally, the correspondence between anatomic and metabolic changes will be investigated by combining MRI images with fluorodeoxyglucose Positron Emission Tomography.