DISRUPTION OF RIGHT-LATERALIZED FRONTO-STRIATAL FUNCTIONAL CIRCUITRY IN FRAGI-X

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言： 我们的实验室(Hoeft等人，2007年)最近使用fMRI对患有脆性X综合征的参与者进行GO/Nogo任务的成像。在任务的NOGO部分，我们发现在脆性X组的同一回路中，活跃的健壮的、右侧的额纹状体回路活跃于典型的发育中的参与者。 具体目标： 在目前的研究中，我们想要评估全脑功能连接(心理生理相互作用；PPI)分析，使用先前成像的10名患有脆性X的男性青少年组，以及10名匹配的典型发育对照组和第三组年龄匹配、发育迟缓的对照组参与者。这项研究的目的是确定在患有脆性X的参与者中，尾状核是否特定地显示出与额叶皮质的异常功能连接。 方法： 为了测试这一点，我们进行了心理生理相互作用(PPI)功能连接性分析，使用右侧和左侧尾状头和身体作为种子感兴趣区(ROI；右侧和左侧，分别为感兴趣ROI和对照ROI)。时间序列从解剖定义的感兴趣区域内的阈值上的体素中提取，并与感兴趣的影响(Nogo与Go纪元)卷积，并用作一般线性模型(GLM)中的回归变量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Our lab (Hoeft et al, 2007) recently used fMRI to image participants with fragile X syndrome as they performed the Go/Nogo task. In contrast to the robust, right-lateralized fronto-striatal circuit active in typically developing participants during the Nogo portion of the task, we found reduced activation in this same circuit in the fragile X group. Specific Aims: In the present study, we wanted to assess whole-brain functional connectivity (psychophysiological interaction; PPI) analyses using the previously imaged group of 10 male adolescents with fragile X as well as 10 matched typically-developing controls and a third group of age-matched, developmentally-delayed control participants. The goal of this study was to determine whether the caudate specifically showed abnormal functional connectivity with the frontal cortex in participants with fragile X. Methods: To test this, we performed psychophysiological interaction (PPI) functional connectivity analyses using right and left caudate head and bodies as seed regions-of-interest (ROIs; right and left, ROI of interest and control ROI, respectively). Time-series were extracted from suprathreshold voxels within anatomically defined ROIs for each subject and were convolved with the effects of interest (Nogo vs. Go epochs), and used as regressors in the general linear model (GLM).