HIGH-RESOLUTION FMRI OF THE MEDIAL TEMPORAL LOBE DURING DELAYED-MATCH-TO-SAMPLE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 介绍： 内侧颞叶（MTL）是众所周知的关键长期记忆的事件和事实。然而，最近的功能性神经影像学和神经心理学的数据，使用短延迟任务的范例表明，MTL有助于性能，即使在短暂的保留间隔。此外，啮齿动物的单单位数据表明，在延迟非匹配样本任务的背景下，在MTL的性能相关的延迟活动。 具体目标： 在目前的研究中，健康成年人进行了扫描，使用高分辨率的功能磁共振成像，以探讨人类MTL亚区的贡献，在一个短延迟（30秒）延迟匹配到样本的任务。 方法和材料： 在一半的试验中，呈现两张面孔（1秒），然后是30秒的延迟，之后参与者遇到了两个选择的强迫选择探针（720次试验）。在另一半试验中，延迟时间为4 s。 参与者在3 T扫描仪上使用螺旋进出BOLD序列进行扫描。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: The medial temporal lobe (MTL) is known to be critical for long-term memory for events and facts. However, recent functional neuroimaging and neuropsychological data using short-delay task paradigms have suggested that the MTL contributes to performance even after brief retention intervals. Moreover, single-unit data in rodents have demonstrated performance-related delay activity in the MTL in the context of delayed-non-match-to-sample tasks. Specific Aims: In the current study, healthy adults were scanned using high-resolution functional MRI to explore the contributions of human MTL subregions to performance during a short-delay (30 s) delayed-match-to-sample task. Methods and Materials: On half of the trials, two faces were presented (1 s), followed by a 30-s delay, after which participants encountered a two-alternative forced choice probe (720 trials). On the other half of trials, the delay period was 4 s. Participants were scanned on a 3T-scanner using a spiral in-out BOLD sequence.