NOVEL PROTEIN-PROTEIN DOCKING TOOLS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 蛋白质-蛋白质相互作用在酶复合物的形成、转录调节和离子通道调节以及许多基本细胞过程中至关重要。然而，目前用于计算方法的蛋白质-蛋白质相互作用算法仍然在精度和速度方面受到限制。我们建议开发新的蛋白质-蛋白质对接方法与先进的用户界面环境。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Protein-Protein interaction is critical in the formation of enzymatic complexes, transcriptional regulation, and ion channel regulations, and many essential cellular processes. However, current protein-protein interaction algorithms used in computational approaches are still limited in both accuracy and speed. We propose to develop novel protein-protein docking methods with an advanced user interface environment.