MECHANICS OF BLOOD FLOW IN MICROVESSELS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 超级计算机资源的这一提案是为了支持授予PI的两个NSF资助的提案（BES-0603035和CTS-0625936）。该提案的目的是开发计算流体动力学模型和模拟，以研究可变形颗粒的流体动力学。重点将放在直径为10- 300 μ m的微血管中的多个血细胞的血液动力学上，这是微循环和微流体装置的典型特征。重点是能够考虑大量的变形血细胞，$\sim$ O（500）的数量的动态，同时解决每个单独的细胞内的变形和流动。为此，我们在NCSA使用IBM P690开发全三维代码，使用嵌入边界方法的变形细胞，并结合傅立叶-有限差分格式的流动求解器。我们还通过一个简单的化学动力学方法耦合相邻细胞之间的分子相互作用和细胞与血管壁之间的流体动力学。利用过去的分配，我们已经开发了三维代码，并解决了一些问题，在微血管中的单和双变形细胞的流体动力学。我们将继续对多细胞进行研究，因此请求NCSA继续提供支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal for supercomputer resource is to support two NSF-funded proposals awarded to the PI (BES-0603035 and CTS-0625936). Objective of the proposal is to develop computational fluid dynamic models and simulation to study the hydrodynamics of deformable particles. The focus will be on the hemodynamics of multiple blood cells in microvessels of 10--300$\mu$m diameter, typical of microcirculation and microfluidic devices. The emphasis is on the ability to consider the dynamics of a large population of deformable blood cells, $\sim$ O(500) in number, while resolving the deformation of and the flow inside each individual cell. To that end, we are using the IBM p690 at NCSA to develop fully three-dimensional code using immsersed boundary methods for deformable cells, and combined Fourier--Finite difference scheme for the flow solver. We also couple molecular interaction between the adjacent cells and between a cell and a blood vessel wall to the hydrodynamics via a simple chemical kinetic approach. Using the past allocation, we have developed the 3D code, and addressed some problems related to the hydrodynamics of single and binary deformable cells in microvessels. We continue to pursue research on multiple cells, and hence request for continued support from NCSA.