Identification of Molecular Signatures in Indigenous and Non-Indigenous Australians with Systemic Lupus Erythematosus to Enable a Precision Medicine Approach.

狼疮是一种无法治愈的疾病，在澳大利亚土著人中更为普遍和严重。然而，对此的生物学解释从未被探索过。在血液中可测量的标记数以千计。为了发现新药，需要高度复杂的数据分析方法，即生物信息学，来分析这些血液标志物的“堆栈”。这项研究将是澳大利亚土著狼疮患者的第一项研究，并将有助于患者选择新兴药物。

Lupus is an incurable illness, strikingly more prevalent and severe in Indigenous Australians. The biological explanation for this has, however, never been explored. Markers measurable in the blood number in the thousands. To discover new drugs, highly complex data analysis methods, known as bioinformatics, are required to analyse the ‘stack’ of these blood markers. This study will be a first in Indigenous Australians with lupus, and will help in patient selection for emerging drugs.