Identification of Mycobacterial Gene Products that Modulate Host Inflammation

结核病每年夺去近200万人的生命。结核病通过引导免疫细胞对感染发起无效反应来破坏宿主免疫力。其中一个技巧是从宿主那里劫持一类叫做类花生酸的分子的控制权。该项目将使用经过验证的结核病感染斑马鱼模型来确定分枝杆菌破坏正常类花生酸生产的机制。这项工作的发现可能有助于创造新的抗结核病疗法。

Tuberculosis (TB) claims almost two million lives every year. TB subverts host immunity by directing the immune cells to launch an ineffective response to infection. One such trick is to hijack control of a class of molecules called eicosanoids from the host. This project will use a validated zebrafish model of TB infection to pinpoint the mechanisms used by mycobacteria to subvert normal eicosanoid production. Findings from this work may to aid the creation of novel anti-TB therapies.