Diabetes Prevention in People from Bangladesh; A Pilot Trial in East London

成年后患糖尿病的人数正在增加，在欧洲，未来10年将至少增加50%。这个问题在南亚血统的人中尤其严重，那里的T2D患病率是T2D的3-6倍，与欧洲白人相比，这种疾病出现的时间要早10-15年。南亚人患T2D的终生风险约为三分之一，在印度城市，最近的调查显示，在20岁以上的所有成年人中，有四分之一的人存在T2D和糖耐量受损(IGT)。此外，在20岁以下的人群中，随着欧洲和北美肥胖率的增加，T2D的增长令人震惊。这种慢性疾病会导致心脏病发作、中风、视力丧失和肾衰竭的增加，在英国，这种慢性病约占NHS医疗支出的十分之一。从美国、芬兰和印度的研究中，我们知道，通过锻炼计划、改变饮食以及使用一种药物(二甲双胍)来预防糖尿病是可能的。我们建议进行一项研究，以确定正确的方法，以测试这种类型的计划是否会在伦敦东部的少数族裔群体-孟加拉人社区-在糖尿病高危人群中成功预防。

The number of people developing diabetes as adults is growing and in Europe set to increase by at least 50% in the next 10 years. The problem is particularly intense in people of south Asian origin, where there is 3-6 times prevalence of T2D and the disease presents 10-15 years earlier compared to white Europeans. The lifetime risk for T2D in South Asians is around one in three, and in urban India recent surveys would suggest that T2D and impaired glucose tolerance (IGT) are present in 1 in 4 of all adults over the age of 20 years. Furthermore, in people under the age of 20 years of age there is an alarming increase in T2D associated with increasing prevalence of obesity in Europe and North America. This chronic disease results in increased heart attacks, strokes, loss of vision and kidney failure and in the UK accounts for approximately one tenth of the NHS health expenditure. From research in the US, Finland and India, we know it is possible to prevent diabetes with a programme of exercise and changes in diet, as well as use of a drug (metformin). We propose a research study to determine the right methods to test whether this type of programme will be successful in preventing diabetes in people at high risk of the disease in an ethnic minority group, the Bangladeshi community in east London.