High-Resolution Structure/Function Analysis of the Strand-Loop Network of RNA Polymerase

大多数细胞含有相同的遗传物质，这些遗传物质编码各种细胞成分的结构。细胞类型的不同（例如神经元与肌肉细胞的不同）是因为遗传物质的不同部分被选择性地读出而产生的。RNA聚合酶（rnap）是参与这种选择性阅读机制的分子机制的关键部分。为了更好地理解正常和病理细胞状况，我们需要对RNAP功能的分子机制有更深入的了解。这些知识将导致更有针对性的治疗应用，新的诊断工具，并有助于开发新型抗生素

The majority of cells contain the same genetic material that encodes the structure of various cellular components. Differences in cell types (e.g. neurons as compared to muscle cells) arise because different parts of the genetic material are selectively read out. RNA polymerases (RNAPs) are a crucial part of the molecular machinery involved in this selective reading mechanism. To understand normal and pathological cellular conditions better we need to gain an improved insight of the molecular mechanisms underlying RNAP function. Such knowledge will result in more specifically targeted therapeutic applications, new diagnostic tools and help with the development of novel types of antibiotica