Malaria Adenoviral Vaccine

疟疾是全球传染性死亡的最大原因之一，但目前尚无疫苗。十多年来，人们已经知道，一种特殊类型的免疫反应可以对疟疾提供强有力的保护。这需要杀伤T细胞对生长在肝细胞中的疟原虫产生细胞免疫反应。一种可以携带疟疾基因的新型减毒安全病毒已经被开发出来，作为一种疫苗，它可以非常强烈地诱导这些杀伤细胞，防止啮齿动物感染疟疾。我们将研制一种这种类型的疫苗，并测试其保护接种疫苗的个人免受疟疾感染的能力。如果成功的话，这种方法将有助于开发针对多种其他疾病的类似疫苗。

Malaria is one of the greatest causes of infectious mortality globally but no vaccine is available. For over ten years it has been known that a particular type of immune response can impart strong protection against malaria. This entails a cellular immune response by killer T cells against the malaria parasite growing in liver cells. A new type of attenuated safe virus that can carry malaria genes has been developed as a vaccine that can induce these killer cells very strongly and protect against rodent malaria. We shall generate a vaccine of this type and test its ability to protect vaccinated individuals against malaria infection. If successful this approach could help develop vaccines of a similar type against a variety of other diseases.