The uses and outcomes of treatment of HIV infection in the UK

在过去的十年里，用于治疗艾滋病毒的药物有了显著的改进，导致英国和其他发达国家死于艾滋病的人数大幅减少。然而，这些药物可能有副作用，其中一些可能危及生命，这可能使患者难以服用所有的药片。此外，如果患者忘记在正确的时间服用药片，或者服用的药片比他们应该服用的少，可能会产生对这些药物或他们将来可能接受的其他药物不起作用的艾滋病毒株。尽管在这种情况下可以使用许多治疗方法，但人们担心，在某些阶段，患者可能会用尽治疗选择，并可能再次开始生病和死亡。作为该应用程序的一部分，我们将结合使用数据分析和数学建模来调查可能出现这种情况的条件。这将使我们能够确定更有效地使用这些治疗方法的方法，以尽量减少发生这种情况的风险。

Over the last ten years, the drugs used to treat HIV have improved dramatically, leading to huge reductions in the number of people dying from AIDS in the UK and in other developed countries. However, these drugs may have side effects, some of which may be life-threatening, which may make it difficult for a patient to take all of their tablets. Furthermore, patients who forget to take their tablets at the right time, or who take fewer tablets than they are supposed to, may develop HIV strains that don’t respond to these drugs, or to other drugs that they may receive in the future. Although there are a number of treatments that can be used if this happens, there is a worry that at some stage, patients may run out of treatment options and may once again start to become sick and die. As part of this application we will use a combination of data analysis and mathematical modelling to investigate the conditions in which this situation could arise. This will allow us to identify ways in which these treatments could be used more effectively, to minimise the risk of this happening.