Virus specific memory T cell responses in H5N1 avian influenza virus infected patients

这项研究的目的是研究人体如何对禽流感病毒感染作出反应，特别关注杀死流感病毒感染细胞的白细胞（称为杀伤t细胞）。我们会问这些T细胞反应有多大，它们是否只对禽流感病毒起反应，或者那些T细胞能识别普通流感毒株的人是否对禽流感有一定的保护？这些t细胞反应是否在保护那些接触过禽流感但没有生病的人方面发挥了作用？或者是否有可能，对更常见的流感病毒株具有t细胞免疫的人实际上可能会导致接触禽流感a病毒株的人患病？

The aim of this study is to study how the human body can respond to avian influenza virus infection, focusing specifically on white blood cells (called killer T-cells) that kill influenza-virus-infected cells. We will ask how big are these T cell responses and do they react only to avian virus or will people whose T-cells recognise the common flu strains have some protection against avian flu? Do these T-cell responses play a part in protecting people who have been exposed to avian flu but who did not become sick? Or is there a possibility that having T-cell immunity to the more common influenza virus strains could actually cause disease in people who are exposed to avian strains of influenza A virus?