Identification and quantification of HIV Latency biomarkers in the Central Nervous System

治愈艾滋病毒的一个主要障碍是大脑作为艾滋病毒感染的潜在宿主所扮演的角色。鉴于目前抗逆转录病毒药物治疗脑部感染的能力各不相同，目前尚不清楚艾滋病毒的“再觉醒”是否会导致无法控制的脑损伤。并不是所有的患者都有艾滋病毒脑部感染，因此根除疗法本身可能是安全的。我们的目标是识别和量化大脑中艾滋病毒潜伏期的生物标记物，以将患者分为这两个队列。

One major obstacle in curing HIV is the brain’s role as a potential reservoir of HIV infection. It is unknown if “reawakening” of HIV may lead to uncontrollable brain damage given that current antiretroviral drugs vary in their ability to treat brain infection. Not all patients have HIV brain infection so eradication therapies in themselves may be safe. We aim to identify and quantify biomarkers of HIV latency in the brain to stratify patients into these two cohorts.