Training in Lung Molecular and Cell Pathobiology-Phase II

描述（由申请人提供）：杜兰大学在肺部疾病的生物医学和基础分子研究方面已经有了坚实的基础。1992年，作为杜兰大学校园范围内战略计划的一部分，该计划旨在改善和现代化肺部研究活动，使其进入细胞和分子病理生物学领域。Mitchell Friedman（首席研究员）和Arnold Brody（联合首席研究员）被招募到杜兰大学医学中心。弗里德曼博士是杜兰大学医学中心（Tulane University Medical Center）的医学教授和肺病、重症监护和环境医学科主任。他目前是杜兰大学病理学教授，病理学部副主席，Tulalae肺生物学项目主任。随着博士的招募。弗里德曼和布罗迪一个坚实的和高度竞争的肺病研究项目已经发展成为高度合作的肺生物学项目在杜兰大学在过去的七年。肺生物学项目的个别教员代表了医学院的两个部门（医学、病理学），这些研究人员每年获得的所有研究奖励总额约为300万美元。此外，杜兰大学Ltmg生物学项目与杜兰大学的其他研究中心（包括基因治疗中心、生物医学工程系、药学系和杜兰大学癌症中心）之间开展了重要的互动研究项目。现在，每年授予全体教员的联邦和非联邦资金的直接费用总额约为10,200,000美元。该研究奖励级别包括来自NIH、DoD、NIOSH、LA州、协会和基金会的资助。作为教师生产力的一个例子，1998-2002年间，在著名期刊上发表了大约113篇论文，并在国内和国际会议上发表了许多演讲。主要研究方向为肺纤维化机制、肺癌、肺循环、哮喘、COPD、基因治疗、吸入有毒物质对肺部和气道炎症机制的影响。自1992年以来，杜兰大学在肺细胞和分子病理生物学方面的研究人员和研究项目的快速增长也与博士前和博士后培训活动的发展有关。目前有23名学员接受培训教师的指导。这些受训者的资金目前来自于个别教师的研究补助金和合同，杜兰大学分子和细胞生物学项目和杜兰大学/泽维尔大学生物环境研究中心的资金，以及基金会和捐赠。肺部、重症监护和环境医学科还为肺部和重症监护医学的9名临床研究员提供培训。培训项目的多样性体现在以下事实中：9名女性、3名黑人、1名美洲原住民和7名亚洲人。自1992年以来，已有64名博士后学员获得学术职位。在肺部疾病的细胞和分子水平上广泛的研究活动，教师的成就和培训的记录，为我们的学员提供了优秀的研究经验，教师和受训者的生产力，证明了他们的出版记录和资助资金，以及一些受训者已经获得教师职位的事实，作为提交这项新的T-32培训补助金的基础，提供资助的肺细胞和分子病理生物学的正式研究培训。本项目主要目标是培养以肺细胞和分子生物学为重点，研究肺部疾病基本机制的高素质博士后。该计划的学员将利用新兴技术和新方法，获得设计和开展病理生物学基础研究的必要技能。我们制定了一个正式的2年培训计划（一个有指导的实验室研究项目和一个正式的核心课程），为学员在肺生物学研究方面发展成功和独立的学术生涯做好准备。

Description (provided by applicant): A solid base of biomedical and basic molecular research in lung diseases has evolved at Tulane University. In 1992, as part of a campus wide strategic plan by Tulane to improve and modernize the lung research activities into the areas of cell and molecular pathobiology Drs. Mitchell Friedman (Principal Investigator) and Arnold Brody (Co-Principal Investigator) were recruited to Tulane University Medical Center. Dr. Friedman is Professor of Medicine and Chief of the Section of Pulmonary Diseases, Critical Care and Environmental Medicine at Tulane University Medical Center. Dr. Brody is currently Professor of Pathology, Vice Chairman of the Department of Pathology at Tulane and Director of the Tulalae Lung Biology Program. With the recruitment of Drs. Friedman and Brody a solid and highly competitive lung disease research program has evolved into the highly collaborative Lung Biology Program at Tulane University over the past seven years. The individual faculty members of the Lung Biology Program represent two departments in the Medical School (Medicine, Pathology and the total amount of all research awards to these investigators is approximately $3 million/year. Furthermore, critical interactive research programs have been developed between the Tulane Ltmg Biology Program and other research centers at Tulane including the Center for Gene Therapy, Department of Biomedical Engineering, Department of Pharmacology, and thc Tulane Cancer Center. The total federal and non-federal monies awarded to the entire faculty on a yearly basis is now approximately $10,200,000 in direct costs. This research award level includes grants from the NIH, DoD, NIOSH, State of LA, associations, and foundations. As an example of productivity of the faculty, for 1998-2002, there have been approximately 113 publications in prestigious journals and numerous presentations at national and international meetings. The main research areas are in mechanisms of lung fibrosis, lung cancer, pulmonary circulation, asthma, COPD, gene therapy, and effects of inhaled toxicants on the lung and airway inflammation mechanisms. The rapid growth of research faculty and research projects in lung ceil and molecular pathobiology at Tulane since 1992 has also been associated with the development of pre-doctoral and post-doctoral training activities. There are presently 23 trainees being mentored by the training faculty. The funding for these trainees are presently derived from individual faculty research grants and contracts, funding from the Tulane Molecular and Cell Biology Program and the Tulane/Xavier Center for Bioenvironmental Research, and foundations and endowments. The Pulmonary, Critical Care and Environmental Medicine Section also provides training for 9 clinical fellows in Pulmonary and Critical Care Medicine. The diversity of the training program is exemplified by the fact that of these trainees, 9 were female, 3 Black, 1 Native American and 7 Asian. The Training program faculty, since 1992, have had 64 post-doctoral trainees obtain academic faculty positions. The wide range of research activities at the cell and molecular level in lung disease, the track record of achievement and training by the faculty, the development of excellent research experience for our trainees, the productivity of the faculty and trainees as evidenced by their publication record and grant funding and the fact that a number of trainees have obtained faculty positions serve as the basis for the submission of this new T-32 training grant to offer funded formalized research training in lung cell and molecular pathobiology. The main objective of this proposal is to train highly-qualified post-doctoral students in basic mechanisms ef lung disease focusing on lung cell and molecular biology. Trainees in the Program, utilizing emerging technologies and new approaches, will acquire the necessary skills to design and conduct basic research studies in pathobiology. We have developed a formalized 2-year training program (a mentored laboratory research project and a formalized core curriculum) to prepare the trainees to develop a successful and independent academic career in research in lung biology.