Investigation into the role of phosphatidylinositol 3,5-bisphosphate and AP-1 in multivesicular body protein sorting

每种动物都是由被称为细胞的精确排列的小积木组成的。每个细胞的内部都是高度有序的。在细胞内，机制对包括蛋白质在内的成分进行分类，并将它们发送到正确的隔间。蛋白质分选对许多过程都是必不可少的，包括控制细胞分裂以及免疫和神经系统的正确运作。这些过程中的缺陷可能会导致疾病。像HIV这样的病毒接管了蛋白质分离所需的细胞机器，并利用它从细胞中逃脱。对酵母细胞系统的研究已经在蛋白质分选方面产生了重要的信息，因为酵母细胞具有所有(包括人类)细胞共同的基本细胞机制，而且它们生长迅速，易于操作。我们的工作，使用酵母细胞系统，旨在了解一个特定的细胞蛋白质分选系统是如何发挥作用的。这项研究的结果将提供有关蛋白质分选的基本机制的信息，必须了解这些机制才能开发出对各种人类疾病的有效治疗方法。

Every animal is made up of precisely arranged small building blocks called cells. The inside of each cell is highly organized. Within the cell, mechanisms sort the components, including proteins, and send them to the correct compartments. Protein sorting is essential for many processes including the control of cell division and correct functioning of the immune and nervous systems. Defects in these processes can lead to disease. Viruses such as HIV take over the cellular machinery required for protein sorting, and use it to escape from the cell. Studies of the yeast cell system have yielded important information on protein sorting, as yeast cells have the basic cellular machinery common to all (including human) cells, and they are fast-growing and easy to manipulate. Our work, using the yeast cell system, aims to understand how one particular cellular protein sorting system functions. The results obtained from this study will provide information about the basic mechanisms of protein sorting which must be understood in order to develop effective treatments for a variety of human diseases.