Functional characterisation of the major susceptibility locus (PSORS1) for cutaneous inflammation in psoriasis

皮肤是环境诱因的基本屏障，能够防止对身体的挑战，自然防御机制包括复杂的免疫监视网络。牛皮癣是一种终生皮肤病，是一组与慢性刺激和炎症有关的常见疾病之一。现有证据表明，屏障保护能力存在根本性缺陷，免疫网络调节失调，或者这些因素通过皮肤和免疫途径之间的异常通信而结合在一起。为了开发新的有效的治疗方法，现在需要清楚地了解这些过程和表现出牛皮癣发病风险的根本缺陷。从人类基因组的一个明确定义的区域，我们已经启动了一系列研究，旨在描述导致疾病发展风险大大增加的主要变化。在预防或治疗牛皮癣的更有效方法方面取得进展，预计将在短期和长期内减轻慢性炎症的沉重负担，从而与目前对这种疾病的治疗相比，带来显著的健康和经济效益。

Skin presents an essential barrier to environmental triggers capable of preventing challenge to the bodies natural defence mechanisms which includes a sophisticated immune surveillance network. Psoriasis, a life long skin disorder, is amongst a group of common conditions associated with chronic irritation and inflammation. Available evidence points to a fundamental defect in the capacity for barrier protection, dysregulation of the immune network or a combination of these through abnormal communication between skin and immune pathways. In order to develop new and effective therapies, a clear understanding of these processes and the fundamental defects that characterise the risk of developing psoriasis is now required. From a well defined region of the human genome, we have set out a series of studies designed to characterise the primary alterations that generate a very much increased risk disease development. Progress towards more effective ways to prevent or cure psoriasis would be expected to cut both in the short and long term, the heavy burden of chronic inflammation, and thus lead to a significant health and economic benefits compared to the present management of this disorder.