Identifying conserved alternative splicing mechanisms in vivo

在这项资助中，我们将研究两种蛋白（Mbl和Rbfox）调节选择性剪接的机制。选择性剪接可以从同一基因中产生多种蛋白质，从而有助于连接大脑所需因素的多样性。Mbl和Rbfox的缺陷在许多神经系统疾病中都有报道，我们的目标是了解它们是如何工作的，这样我们就可以设计出调节它们功能的治疗策略。

In this grant, we will investigate mechanisms used by two proteins (Mbl and Rbfox) to regulate alternative splicing. Alternative splicing can produce multiple proteins from the same gene and thereby contribute to the diversity of factors required for wiring-up the brain. Defects in Mbl and Rbfox have been reported in numerous neurological diseases and our goal is to understand how they work so that we can design therapeutic strategies that modulate their function.