MT COBRE: CORE FACILITY DEVELOPMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 COBRE项目的一个主要目标是通过发展核心设施，增加调查人员获得最先进设备的机会，从而提高研究竞争力。核心环境的另一个目的是促进核心用户和核心主任之间的互动和协作，并促进技术信息的交流。研究人员可以使用校园内六个急需的核心研究设施（CRF）。 其中四个CRF由COBRE CSFN直接资助：分子组织学和荧光成像，分子计算和建模，生物光谱学，分子生物学和病毒生产。 在过去的获奖期间，质谱和蛋白质组学核心被整合并归入两个新的核心，神经分子生产核心实验室（CLNP）和分子生物学和病毒生产核心（MBVP）。这些新的核心如下所述。该中心的CRF不仅得到了目前的COBRE奖的支持，而且还得到了大学研究办公室和蒙大拿州的匹配资金，以及NIH和NSF授予UM的赠款。 通用报告格式继续发展，并按计划不仅有助于加强个别项目，而且有助于促进合作。 从这些核心中产生的项目已经开始出版，并作为一个关键资源被列入CSFN调查员的一些受资助的R 01申请以及提交的申请中。在这方面应当指出，几乎在所有情况下，通过中心提交的赠款摘要都将研究环境描述为对拟议项目非常有利。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major goal of the COBRE project is to enhance research competitiveness by increasing the access investigators have to state-of-the-art equipment through the development of core facilities. An additional aim of the core environment is to foster interaction and collaboration between core users and core directors and to promote the exchange of technical information. Investigators have access to six critically needed Core Research Facilities (CRFs) on campus. Four of these CRFs are directly funded by the COBRE CSFN: Molecular Histology and Fluorescence Imaging, Molecular Computation and Modeling, BioSpectroscopy, and Molecular Biology and Viral Production. In the past award period, the Mass Spectroscopy and Proteomics Core was integrated and subsumed into two new cores, the Core Laboratory for Neuromolecular Production (CLNP) and the Molecular Biology and Virus Production Core (MBVP). These new cores are described below. The Center CRFs are supported not only by the present COBRE award, but also by the University Research Office and State of Montana match funding, as well as by NIH and NSF grants awarded to UM. The CRFs have continued to develop and, as planned, have served not only to enhance individual projects but also to promote collaborations. Projects emerging from these cores have begun to produce publications and to be included as a critical resource in a number of funded R01 applications by CSFN investigators as well as in submitted applications. It should be noted in this regard that in almost every instance the summary statements from grants submitted through the Center characterize the research environment as excellent/very supportive of the proposed projects.