DF/HCC SPORE in Gastrointestinal Cancer

描述（由申请人提供）：本申请代表了源自Dana- Farber/Harvard癌症中心（DF/HCC）胃肠道（Gl）恶性肿瘤项目的胃肠道癌症卓越研究专业项目（SPORE）的创建。Gl癌中DF/HCC孢子的主要目标是将生物学和技术进步转化为预防、诊断、预后预测和胃肠道恶性肿瘤治疗方面的改进。Gl癌症中的DF/HCC孢子包括来自所有哈佛附属医院的研究人员：丹娜-法伯癌症研究所、布里格姆妇女医院、马萨诸塞州总医院、贝斯以色列女执事医疗中心、波士顿儿童医院和哈佛公共卫生学院。拟开展五大项目：1)改善胰腺癌术前分期；2)分子荧光成像在结直肠肿瘤早期检测中的应用；3)确定黑人化学预防维生素D的最佳剂量；4) pi3激酶信号通路在结直肠癌抗egfr治疗敏感性和耐药中的作用；5)胃肠道间质瘤靶向治疗耐药机制。这些项目将通过创建四个核心来整合：1)行政，评估和规划；2)组织病理学；3)生物统计学和4)基因组学和生物信息学。《孢子》申请概述了一个发展项目计划，其中包括一个选择新项目的计划，以及9个可以支持的试点项目。我们还包括一个职业发展奖励计划，该计划概述了识别和支持有才华的年轻癌症研究人员的机制。本申请中提出的项目和核心与现有的DF/HCC核心资源高度整合，并涉及与其他现有孢子的研究人员的关键合作。这个Gl孢子在DF/HCC的创建将把哈佛大学在基础、转化和临床科学方面的领先研究人员结合到一个项目中，该项目具有在Gl癌症的诊断、治疗和预防方面产生有意义的进展所需要的重点和协调。

DESCRIPTION (provided by applicant): This application represents the creation of a Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer originating from the Gastrointestinal (Gl) Malignancies Program of the Dana- Farber/Harvard Cancer Center (DF/HCC). The main goal of the DF/HCC SPORE in Gl Cancer is the translation of biological and technological advances into improvements in prevention, diagnostics, predictors of outcome, and advances in the treatment of gastrointestinal malignancies. The DF/HCC SPORE in Gl Cancer includes researchers from all Harvard-affiliated hospitals: the Dana-Farber Cancer Institute, the Brigham and Women's Hospital, the Massachusetts General Hospital, the Beth Israel Deaconess Medical Center, Children's Hospital of Boston, and Harvard School of Public Health. Five major projects are proposed including: 1) Improved pre-operative staging of pancreatic cancer; 2) Molecular fluorescent imaging for the early detection of colorectal neoplasms; 3) Defining optimal doses of vitamin D for chemoprevention in Blacks; 4) The role of PI3-Kinase signaling pathway in defining sensitivity and resistance to anti-EGFR therapy in colorectal cancer; and 5) Targeted therapy resistance mechanisms in gastrointestinal stromal tumor. These projects will be integrated by the creation of four cores: 1) Administration, Evaluation & Planning; 2) Tissue and Pathology; 3) Biostatistics and 4) Genomics and Bioinformatics. The SPORE application outlines a Developmental Projects Program that includes a plan for selection of new projects as well as nine pilot projects that could be supported. We also include a Career Development Award Program that outlines a mechanism for the identification and support of talented young investigators in Gl cancer. The projects and cores proposed in this application are highly integrated with present DF/HCC core resources, and involve key collaborations with investigators from other existing SPOREs. The creation of this Gl SPORE at DF/HCC will combine leading Harvard researchers in basic, translational, and clinical sciences into a program that has the focus and coordination required to produce meaningful advances in the diagnosis, treatment, and prevention of Gl cancers.