Identifying the mechanism of the G2 phase UV checkpoint and repair response commonly defective in melanoma

阳光中的紫外线成分是导致黑色素瘤发生的主要环境因素。紫外线辐射可以直接突变基因，导致它们无法执行正常功能，这可能会导致癌症。尽管紫外线辐射直接导致大量突变，但已知的修复这些突变的机制在黑色素瘤中通常是正常的。这项研究将调查我们已经确定的在黑色素瘤中普遍存在缺陷的修复机制。

The UV component of sunlight is the major environmental factor driving the development of melanoma. UV radiation can directly mutate genes resulting in their inability to perform normal functions which may contribute to cancer. Despite the high number of mutations directly attributable to UV radiation, the mechanisms known to repair these mutations are generally normal in melanoma. This research will investigate a repair mechanism we have identified that is commonly defective in melanomas.