Training in bacteriology

描述（由申请人提供）：我们不断发展的微生物学家社区为原核生物学的博士生提供了良好的环境。这一努力目前正在培养高素质的个人，以满足与细菌学以及新出现和再出现的日益严重的细菌性疾病问题有关的国家和国际优先事项。鉴于我们的项目在教师和学员方面的增长，我们重新提交这个提案，在宾夕法尼亚大学建立一个新的美国国立卫生研究院支持的细菌学培训项目。该培训计划每年将支持2-3名博士研究生和1名博士后，使他们能够在12个实验室中的任何一个实验室中获得深入的经验，这些实验室由研究人类、动物或植物细菌生理学或疾病重要方面的首席研究员指导。选择与T32提案相关的培训师是因为他们在这些领域的研究项目已经建立，得到了NIH或其他联邦资助的支持，并且/或者在这些主题上发表了大量文章。原核生物群落的优势之一是多样性，它已经在这所领先的研究型大学的三个学院和六个系之间促进了富有成效的科学互动。这组培训人员涵盖了细菌研究的主要领域，包括主要的细胞外（Weiser，肺炎链球菌和流感嗜血杆菌；Binns，肿瘤杆菌；Yuk，博德特拉菌；Zhu，霍乱弧菌；希弗利，大肠杆菌和鼠疫弧菌）和细胞内(Goldfine，单核细胞增生杆菌；Rubin， M. tuberculosis)病原体，新型疫苗的开发（Paterson， Schifferli和Weiser），免疫发病机制和细菌作为免疫治疗药物的使用（Paterson, Shen, Yuk），细菌细胞表面关键成分的结构和功能（Goulian, Daldal, Pohlschroder）和目标细胞的细菌信号传导（Binns, Goulian, Yuk, Zhu）。在过去的八年中，这些培训师共发表了超过22种细菌的文章，再加上他们实验室的研究主题和技术的广度，为当前和未来的学员提供了大量的研究机会。培训师提供的研究机会，加上强有力的机构承诺和广泛而组织良好的培训计划，有望为学生和博士后提供优秀的细菌学培训。

DESCRIPTION (provided by applicant): Our growing community of microbiologists has developed an outstanding environment for mentoring pre- and postdoctoral trainees in prokaryotic biology. This effort is now producing highly qualified individuals to meet national and international priorities related to bacteriology and to the growing problems of emerging and re-emerging bacterial diseases. Given the growth of our program, both in terms of faculty and trainees, we resubmit this proposal to establish a new NIH-supported Training Program in Bacteriology at the University of Pennsylvania. The Training Program would support 2-3 Ph.D. candidate predoctoral fellows as well as one postdoctoral fellow per year, enabling them to obtain an in-depth experience in any one of 12 laboratories directed by principal investigators who study important aspects of bacterial physiology or diseases of humans, animals or plants. The trainers associated with this T32 proposal have been selected because their research programs in these areas are well established, being supported by NIH or other federal grants and/or having published extensively on these topics. One of the strengths of the prokaryotic community is a diversity that has already fostered productive scientific interactions between three Schools and six Departments at this leading research university. The group of trainers encompasses the major areas of research on bacteria including bacterial-host interactions of leading extracellular (Weiser, S. pneumoniae and H. influenzae; Binns, A. tumefaciens; Yuk, Bordetella spps; Zhu, V. cholerae; and Schifferli, E. coli and V. pestis) and intracellular (Goldfine, L. monocytogenes; Rubin, M. tuberculosis) pathogens, the development of novel vaccines (Paterson, Schifferli and Weiser), immunopathogenesis and use of bacteria as agents in immunotherapy (Paterson, Shen, Yuk), the structure and function of key components bacterial cell surface (Goulian, Daldal, Pohlschroder) and bacterial signaling of target cells (Binns, Goulian, Yuk, Zhu). These trainers have together published articles on over twenty-two bacterial species in the past eight years, which, in conjunction with the breadth of research topics and techniques available in their laboratories, offers numerous research opportunities for current and future trainees. The research opportunities provided by the trainers coupled with strong institutional commitment and an extensive and well-organized training program promises to provide excellent training in bacteriology to both students and postdoctoral fellows.