Developmental Biology Training Grant

描述（由申请人提供）：本申请是为了更新对发育生物学研究生培训计划的支持。 资金要求9个博士前职位，在发育生物学研究计划，其中包括约66名研究生和47名博士后实习生。 在过去的一年中，该计划增加了三名新的教师从事小鼠的发育生物学-这是该计划的一个新的研究领域-以及在进化/发展领域增加了三名教师培训师。 这些变化为我们的核心发育生物学培训计划增加了新的优势和广度。 拟议的培训计划强调个性化的研究生研究培训在一组互动的教师，为每个学生提供不同的培训输入，和一些学生有共同的顾问，让他们从两个实验室整合研究培训。 每个博士前的学生是由指导学生通过一个高度个性化的培训计划教师委员会建议;委员会每年至少召开一次会议，除了许多非正式会议（例如，期刊俱乐部和研究研讨会），导致学生的进步和创造一个支持性的环境良好的监测。 20名教师直接参与该计划。教师都是分子生物学研究所（10），神经科学研究所（7）或生物学系（3）的成员。 俄勒冈州的研究机构的大学提供了一个互动的调查环境;他们带来了共同利益的实验室，运行研究生课程，提供空间和资金支持，并有每年务虚会。 研究所还支持共享的研究设施-如基因组学和蛋白质组学中心，转基因小鼠设施，单克隆抗体设施和生物光学中心-所有人员都配备了专家人员，他们可以为学生提供实验设计的培训和帮助。 分子生物学研究所和神经科学研究所共同提供了一个跨学科的方法来发展生物学，包括计算生物学，结构生物学，细胞生物学，神经科学和进化生物学。 这种培训的广度很好地结合了高度集中的项目为导向的研究培训，学生在他们的主机实验室接受，生产创造性的科学家谁将能够开发自己的一流的研究计划，从而加强在发育生物学的国家资源。 公共卫生相关性：发育生物学的培训对于了解许多疾病中出错的机制至关重要，包括一些毁灭性的出生缺陷，如无脑畸形。 许多成人发病的疾病，如许多癌症，似乎是由于发育程序，不适当地表达在成人。 了解这些疾病并因此设计治疗方法的最佳方法是培养发育生物学的基础和临床科学家。

DESCRIPTION (provided by applicant): This application is to renew support for a developmental biology graduate training program. Funds are requested for nine predoctoral positions, within a developmental biology research program that includes approximately 66 graduate students and 47 postdoctoral trainees. Over the past year the program has added three new faculty working on developmental biology of the mouse ~ a new research area for this program - as well as adding three faculty trainers in the area of evolution/development. These changes add new strengths and breadth to our core developmental biology training program. The proposed training program emphasizes individualized graduate research training within a group of interactive faculty that provides each student with diverse training input, and a number of students have co-advisors allowing them to integrate research training from two laboratories. Each predoctoral student is advised by a faculty committee that guides the student through a highly individualized training program; the committee meets at least once every year, in addition to many informal meetings (e.g., journal clubs and research seminars), resulting in excellent monitoring of the student's progress and the creation of a supportive environment. Twenty training faculty directly participate in the program. Faculty are all members in the Institute of Molecular Biology (ten), the Institute of Neuroscience (seven), or the Department of Biology (three). The University of Oregon's research Institutes provide an interactive investigative environment; they bring together laboratories with common interests, run graduate programs, provide space and funding support, and have annual retreats. Institutes also support shared research facilities - such as the Genomics and Proteomics Center, Transgenic Mouse Facility, Monoclonal Antibody Facility, and Bio-Optic Center - all staffed with expert personnel who are available to the students for training and assistance in experimental design. The Institute of Molecular Biology and Institute of Neuroscience together provide an interdisciplinary approach to developmental biology that includes computational biology, structural biology, cell biology, neuroscience, and evolutionary biology. This breadth of training combines well with the highly focused project-oriented research training the students receive in their host laboratories, producing creative scientists who will be able to develop their own first-rate research programs, thereby strengthening the national resource in developmental biology. PUBLIC HEALTH RELEVANCE: Training in Developmental Biology is essential to understand the mechanisms that go awry in many diseases, including a number of devastating birth defects such as lissencephaly. Many adult onset diseases, such as numerous cancers, appear to be due to developmental programs that are inappropriately expressed in the adult. The best way to understand, and thus design treatments, for these diseases is to train basic and clinical scientists in developmental biology.