Cellular Signaling and Kidney Function

尽管对正常肾脏的肾细胞生理学进行了多年的研究，但对肾细胞生理学的全面研究仍然存在不足。 了解支配全身稳态平衡和相关疾病状态的因素 仍然不完整。然而，很明显，正常的体内平衡和 身体对肾脏病理生理学的异常反应涉及免疫调节剂之间的显著相互作用。 各种肾脏过程、全身激素和体内其他组织的反应。 虽然这些相互作用中的一些已经知道了一段时间， 驱动其它反应如细胞凋亡和增殖反应的方法只是最近才被研究。这 主要是因为现在有了新的工具来研究这些相互作用。有细胞 以及分子生物学方法，这些方法使识别和修饰 负责维持正常体内平衡的人和负责维持正常体内平衡的人 肾脏内和身体其他部位对肾功能丧失的病理生理反应 功能埃默里大学的生理学系和肾脏病学系有一个长期的 研究历史的识别，描述和表征的细胞过程中， 肾脏与正常生理和病理生理有关，以及肾脏病理生理如何 影响身体的其他组织该计划的目标，肾细胞和分子生物学 疾病过程，是为了加强现有的相互作用，并发展新的方向之间的 一个紧密联系的研究小组，他们将使用分子和细胞生物学工具来了解 可导致疾病状态的肾细胞机制的畸变以及这些畸变的影响 其他组织上的疾病状态。项目1是“ENaC组装、贩运、降解和回收” 其将表征肾钠通道蛋白的明显独特的细胞加工。 项目2，“Pendrin在盐皮质激素诱导的高血压中的作用”将研究一种新的调节机制， CCD中氯离子运动的途径。项目3，“胰岛素信号传导和肌肉蛋白质周转 在酸中毒”，检查与肾脏疾病相关的肌肉萎缩的机制。最后一个， 项目4，“MDCK细胞中尿素转运蛋白的调节”，检查肾尿素的调节 在一个新的模型系统中运输蛋白质。

Despite years of research on renal cell physiology in the normal kidney, a comprehensive understanding of the factors that govern total body homeostatic balance and associated disease states is still incomplete. However, it has become quite clear that normal homeostatic balance and the abnormal responses of the body to renal pathophysiology involves significant interaction among a variety of renal processes, systemic hormones, and responses of other tissues within the body. Although some of these interactions have been known for some time, the molecular mechanisms driving others such as apoptotic and proliferative responses have only recently been investigated. This is primarily because of new tools which are now available to study these interactions. There are cellular and molecular biological methods that make it possible to identify and modify the proteins that are responsible for maintaining normal homeostatic balance and those which are responsible for pathophysiological responses within the kidney and elsewhere in the body in response to loss of renal function. The Department of Physiology and the Division of Nephrology at Emory University have a long history of research into the identification, description and characterization of cellular processes in the kidney that are related to normal physiology and pathophysiology and how renal pathophysiology can impact other tissues in the body. The objective of this Program, Cellular and Molecular Biology of Renal Disease Processes, is to reinforce the existing interactions and develop new directions between a closely knit group of investigators who will use molecular and cellular biological tools to understand aberrations in renal cellular mechanisms that can lead to disease states and the impact of these disease states on other tissues. Project 1 is "ENaC Assembly, Trafficking, Degradation, and Recycling" which will characterize the apparently unique cellular processing of renal sodium channel proteins. Project 2, "The Role of Pendrin in Mineralocorticoid-Induced Hypertension" will examine regulation of a pathway for chloride movement in the CCD. Project 3, "Insulin Signaling and Muscle Protein Turnover in Acidosis", examines the mechanisms of muscle wasting associated with renal disease. The last, Project 4, "Regulation of Urea Transporters in MDCK Cells", examines the regulation of renal urea transport proteins in a new model system.