RACIAL DIFFERENCES IN CIRCULATING SEX STEROIDS: MECHANISMS AND EFFECT ON BONE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的总体假设是，性激素水平的升高可能是非洲裔美国女性一生中一些与激素相关的疾病的原因，包括平滑肌瘤、内分泌相关癌症和预防骨质疏松症。如果是这样的话，可能会开始理解对黑人女性的这些过程的贡献，无论是保护性的还是相加性的，也将允许正常月经周期中性类固醇水平的差异，以及确定机制。这项研究将进一步提出检验性类固醇对末端器官的影响--在这种情况下，骨密度和结构。 这项研究的目的是看看女性的水平是否与白人女性相比。如果是这样的话，我们可能会开始了解他们对黑人女性某些疾病的贡献，从而使我们能够改进预防医学上这些疾病的方法。这项研究将测量正常月经周期中激素水平的差异，并确定这些差异的原因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall hypothesis of this study is that elevated sex steroid levels may account for some of the hormone-related conditions that follow throughout life in African-American females, including leiomyomas, endocrine related cancers, and protection from osteoporosis. If so, it may begin to be understood the contribution to these processes, both protective and additive, in Black females, and also will allow differences in sex steroid levels in the normal menstrual cycle, as well as to identify mechanisms. The study will further propose to examine the effects of sex steroids on an end organ-in this case bone mineral density and architecture. The purpose of this study is to see if levels of female compared to white females. If so, we may begin to understand their contribution to certain illnesses in Black females allowing us to improve methods of preventing medical these illnesses. The study will measure differences in hormone levels in the normal menstrual cycle, as well as determine reasons for these differences.