Faculty Recruit for Washington University Diabetic Cardiovascular Disease Center

描述(由申请人提供)：此申请通过NIH P30机制(OD-09-005)寻求国家心肺血液研究所(NHLBI)的支持，以获得资源，为华盛顿大学糖尿病心血管疾病中心(DCDC)招聘一名新的独立助理教授。DCDC是一个最近成立的跨学科研究中心，它将来自不同领域的科学家聚集在一起工作，以促进我们对导致糖尿病患者心肌和血管疾病负担过重的机制的理解，并迅速将新发现转化为诊断工具和治疗方法的开发。在美国疾病控制与预防中心的支持下，跨学科的科学家团队正在探索糖脂代谢紊乱与糖尿病心脏病之间的相互作用。正在进行的项目的目标之一是开发新的基于血液和成像的生物标记物。我们建议招聘的杰出个人，杰弗里·亨德森，医学博士，将为该中心在炎症、感染和动脉粥样硬化之间的交叉点带来新的焦点。亨德森博士还在使用灵敏的质谱学技术识别尿液生物标志物方面拥有独特的专业知识。P30的资源，加上医学部和疾病预防控制中心提供的资源，以及本文所述的全面指导和职业发展计划，将为这位训练有素、非常有前途的人在与NHLBI高度相关的领域取得未来的成功奠定基础。 糖尿病与严重的心血管并发症有关，包括侵袭性动脉粥样硬化和与动脉粥样硬化无关的心力衰竭。糖尿病心血管疾病中心的目标是开发新的生物标志物，以便更有效地诊断和治疗这种心血管疾病。这项P30计划将支持中心招募一名训练有素、有前途的年轻科学家。

DESCRIPTION (provided by applicant): This application seeks support from the National Heart, Lung & Blood Institute (NHLBI) through the NIH P30 mechanism (OD-09-005) for resources to recruit a newly independent assistant professor to the Diabetic Cardiovascular Disease Center (DCDC) at Washington University. DCDC is a recently established interdisciplinary research center that brings together scientists from diverse fields in work to advance our understanding of the mechanisms that contribute to the excess burden of myocardial and vascular disease in diabetics, and to rapidly translate new findings into development of diagnostic tools and therapeutic approaches. Under the auspices of DCDC, interdisciplinary teams of scientists are exploring the interactions between derangements in glucose and lipid metabolism and diabetic cardiac disease. One of the goals of ongoing projects is the development of new blood-based and imaging biomarkers. The outstanding individual we propose to recruit, Jeffrey Henderson, MD, PhD, will bring a new focus to the Center at the intersection between inflammation, infection and atherosclerosis. Dr. Henderson also has unique expertise in the use of sensitive mass spectrometry techniques for identification of urinary biomarkers. The resources of the P30, combined with the resources being provided by the Department of Medicine and DCDC and the thorough mentoring and career development plan described herein, will set the stage for the future success of this well-trained and highly promising individual in an area of high relevance to NHLBI. Diabetes is associated with serious cardiovascular complications including aggressive atherosclerosis and heart failure that is unrelated to atherosclerosis. The goal of the Diabetic Cardiovascular Disease Center is to develop new biomarkers for more effective diagnosis and treatment of this cardiovascular disease. This P30 program will support the recruitment to the Center of a well trained, promising young scientist.