Developmental Research Program

M. D.安德森癌症中心前列腺孢子是 资助转化前列腺癌研究中有前景的试点研究。与初始SPORE一样， 发展研究计划在这个新的建议将强调支持转化研究 这些研究可以产生临床上可检验的假设，帮助我们降低 前列腺癌或改善前列腺癌患者的生活质量。分枝D.安德森癌症中心 前列腺SPORE行政核心将征求不超过两页的意向书， 所有机构研究人员的转化研究，包括SPORE职业生涯的参与者 发展计划。这些申请将由项目主任和联合主任以及筛选 根据客观标准，作为主要研究者和共同主要研究者。调查人员 选定的申请将被要求准备一份五页的建议书，以NIH ROI为模型。作为 适当时，行政核心将帮助研究人员提交建议，以制定翻译 具体目标和研究计划，因为这些研究人员中有许多人没有这方面的专门知识。的 因此，这一过程将是一项重大的教育活动，并将进一步促进创新的发展。 翻译研究概念。这些提案将由SPORE领导人进行审查和优先排序 （主要研究者、研究项目负责人、项目主管和核心主管）。这些项目将 资助期为1年，并可延长一年。发展研究项目将 由项目总监/联合总监、SPORE领导人、执行委员会进行临时评估和年度评估， 以及内部/外部咨询委员会。 在最初的前列腺孢子中资助了15个发展项目。接受开发的研究者 研究补助金报告了255篇与研究有关的出版物（2001 - 2006年）， 2001 - 2008年期间的赠款。共为28项外部审查赠款提供了资金。重要的是，两名研究人员 在最初的SPORE提交中没有担任重要角色的人是主要项目的调查人员，或者 新的前列腺SPORE申报资料中的核心：Drs. Lin（职业发展总监）和Navone （项目4负责人;项目3特别顾问;核心C合作者），强调了 发展研究计划，以确定具有潜在价值的项目和研究人员， 翻译研究

The goal ofthe Developmental Research Program ofthe M. D. Anderson Cancer Center Prostate SPORE is to fund promising pilot studies in translational prostate cancer research. As in the initial SPORE, the Developmental Research Program in this new proposal will emphasize the support of translational research studies that can generate clinically testable hypotheses to help us reduce the incidence and mortality of prostate cancer or improve the quality of life of prostate cancer patients. The M. D. Anderson Cancer Center Prostate SPORE Administrative Core will solicit Letters of Intent of no more than two pages for innovative translational research from all institutional investigators, including participants in the SPORE Career Development Program. These applications will be screened by the Program Director and Co-Director as well as the Principal Investigator and Co-Principal Investigator according to objective criteria. Investigators of selected applications will be asked to prepare a five-page proposal modeled after an NIH ROl. As appropriate, the Administrative Core will help investigators submitting proposals to formulate translational specific aims and research plans, as many of these investigators will not have expertise in this area. The process will therefore be a major educational activity and will further stimulate the development of innovative translational research concepts. The proposals will be reviewed and prioritized by the SPORE Leaders (principal Investigators, research project leaders, program directors, and core directors). The projects will be funded for 1 year and will be renewable for an additional year. Developmental Research projects will be evaluated ad hoc and annually by the Program Director/Co-Director, SPORE Leaders, Executive Committee, and the combined Internal/External Advisory Board. Fifteen developmental projects were funded in the initial Prostate SPORE. Investigators receiving Developmental Research grants reported 255 publications related to the research (2001-2006) supported by their grants during 2001-2008. A total of 28 externally reviewed grants were funded. Importantly, two investigators who did not have significant roles in the initial SPORE submission are investigators in major projects or cores in the new Prostate SPORE submission: Drs. Lin (Director, Career Development) and Navone (Leader, Project 4; Special Advisor, Project 3; Collaborator, Core C), highlighting the importance of the Developmental Research Program in identifying projects and investigators with potential value for translational research.