Animal Models

说明)： 拟议的梅奥诊所卵巢孢子的目的是模拟和促进严格的翻译 卵巢癌研究将带来新的基础和人口科学发现并转化为 为卵巢癌患者提供了改进的干预措施。这个孢子里的四个项目中的三个 格兰特在评估新的干预措施(成像)时，严重依赖于这一建议的动物模型核心 和治疗学)，并改进卵巢癌的实验方法和给药方案 老鼠。为了确保所有的动物实验都能以专家和有效的方式进行， 孢子研究人员使用标准化的模型来研究他们不同的治疗策略 CORE将作为中心资源，并与每个项目的实验室人员合作， 将进行项目中描述的所有动物实验。具体地说，动物核心将：(1) 确保实验小鼠的有效规划、规划和推广，(2)提供必要的 为项目提供便利和动物处理专业知识；(3)提供异种移植和具有免疫能力的小鼠 用于测试新制剂和治疗策略的模型，以及(4)提供兽医专业知识和途径 到监测肿瘤负荷的非侵入性成像策略。重要的是，动物模型核心将确保 (1)动物模型的一致性。通过此核心进行建模将保持 方法和结果，使我们更容易复制我们的发现，并更容易结合来自 其他实验室；(2)为所有项目提供强大的动物建模专业知识。虽然所有的项目团队都有 动物模型的经验，有些人比其他人少。通过提供核心，我们可以确保所有 孢子成员将获得可用的最高水平的技能；(3)跨 关于建模策略的项目。核心将汇集每个项目的调查人员 并为新的合作和加强现有的合作提供一个突出的途径； (4)提高动物使用和护理的效率。这一核心将导致一种有组织的动物使用方法， 最大限度地减少浪费和使用的动物数量，并消除人员冗余。 相关性(请参阅说明)： 动物模型核心将开发和维护卵巢癌的小鼠模型。这些型号是 了解卵巢癌与正常健康组织的复杂相互作用 免疫系统。此外，开发新的疗法需要模型，这些新疗法需要 在人类临床使用之前进行动物试验。

instmctions): The purpose of the proposed Mayo Clinic Ovarian SPORE is to sfimulate and facilitate rigorous translational research in ovarian cancerwork that will take new basic and population science discoveries and convert them to improved intervenfions for women with ovarian cancer. Three of the four projects in this SPORE grant rely heavily on this proposed Animal Models Core for the evaluafion of novel interventions (imaging and therapeufics) and for refining experimental approaches and delivery regimens in ovarian cancer-bearing mice. To ensure that all the animal experimentafion can be performed in an expert and efficient manner, and that SPORE investigators use standarized models for their varying therapeutic strategiesthe Animal Core will serve as a central resource and, in collaboration with the laboratory personnel from each project, will perform all the animal experimentafion described in the projects. Specifically, the Animal Core will: (1) ensure the efficient planning, piurchase and ufilizafion of experimental mice, (2) provide the necessary facilifies and animal handling expertise for the projects; (3) provide xenograft and immunocompetent mouse models for testing of novel agents and therapeutic strategies and (4) provide veterinary expertise and access to non-invasive imaging strategies to monitor tumor burden. Importantly, the Animal Models Core will assure the following: (1) Consistency in animal modeling. Modeling through this core will maintain consistency in methods and outcomes, making it easier to reproduce our findings and easier to combine approaches from other labs; (2) Provision of strong animal modeling expertise to all projects. While all project teams have had experience with animal models, some have less than others. By providing a core, we can ensure that all SPORE members will have access to the highest level of skills available; (3) Opfimal interaction across projects with regard to modeling strategies. The core will bring together the investigators from each project and provide an outstanding avenue for new collaborations and the strengthening of existing collaborafions; (4) Efficiency in animal use and care. This core will result in an organized approach to animal use, minimizing waste and the numbers of animals used and eliminafing redundancy in personnel. RELEVANCE (See instructions): The Animal Models core will develop and maintain murine models of ovarian cancer. These models are necessary for understanding the complex interacfions of ovarian cancer with normal healthy tissues and the immune system. Further, the models are needed for the development of novel therapeutics that require animal tesfing prior to human clinical use.