EXERCISE RESPONSES IN 4 ESRD TREATMENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 接受常规血液透析治疗的终末期肾病（ESRD）患者的运动能力极低，在移植后不久即可显著改善。人们怀疑与尿毒症有关的因素损害了运动中增加氧运输和利用所需的生理系统的正常整合。 人们越来越关注缓慢的每日血液透析（包括每日短时间血液透析和缓慢的夜间血液透析），这增加了所提供的透析并减少了尿毒症体征和症状。我们建议研究接受4种不同方式治疗的ESRD患者：常规血液透析（CHD）（3天/周，3-4小时/治疗），缓慢夜间血液透析（SND）（8小时/治疗，6晚/周），每日短透析（SDD）（2小时/治疗，6天/周）和活体供体移植（RTX），以评估对运动的生理反应和决定因素的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Exercise capacity is extremely low in patients with end stage renal disease (ESRD) treated with conventional hemodialysis and improves significantly shortly after transplantation. It is suspected that factors associated with uremia impair the normal integration of physiological systems required for increased oxygen transport and utilizatoin during exercise. There is growing interest in slow daily hemodialysis (both short daily hemodialysis and slow nocturnal hemodialysis), which increases the dialysis provided and reduces uremic signs and symptoms. We propose to study patients with ESRD treated with 4 different modalities: conventional hemodialysis (CHD) (3 days/week, 3-4 hours/treatment), slow nocturnal hemodialysis (SND) (8 hours/treatment, 6 night/week), short daily dialysis (SDD) (2 hours/treatment, 6 days/week) and living donor transplantation (RTX) to assess differences in physiological responses to and determinants of exercise.