SEX DIFFERENCES IN NEUROENDOCRINE AND IMMUNOLOGIC RESPONSES IN IRRITABLE BOWE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标： 通过研究男性和女性健康对照和肠易激综合征（IBS）患者，本研究的目的是：1）确定女性和男性在下丘脑-垂体-肾上腺（HPA）轴反应性和交感神经系统（SNS）激活方面是否不同，2）将这些发现与结肠组织炎症和细胞因子谱的标志物相关联，以及3）确定结肠组织改变是否与内脏疼痛敏感性的性别相关差异有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: By studying male and female healthy controls and irritable bowel syndrome (IBS) patients, the purposes of this study are: 1) to determine if females and males differ in hypothalamic-pituitary-adrenal (HPA) axis responsiveness and sympathetic nervous system (SNS) activation, 2) to correlate these findings with markers of colonic tissue inflammation and cytokine profiles, and 3) to determine if colonic tissue alterations are related to sex-related differences in visceral pain sensitivity.