EARLY TREATMENT OF ALS W NUTRITION & NON-INVASIVE POSITIVE PRESSURE VENTILATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的主要目的是调查常规和早期积极营养和呼吸干预对生存、功能结局和生活质量的影响。次要目标包括开发和验证改善NIPPV(无创正压通气)耐受性的策略；评估早期呼吸功能障碍的测量方法，并确定ALS患者的能量平衡。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this study is to investigate the effect of conventional versus early aggressive nutritional and respiratory intervention on survival, functional outcome and quality of life. Secondary objectives include the development and validation of strategies to improve tolerability of NIPPV (non-invasive positive pressure ventilation); evaluation of measurements of early respiratory dysfunction and determination of energy balance in ALS.