STRUCTURAL MRI MARKERS IN PARKINSON'S DISEASE PROGRESSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项临床研究，将检验这一假设，即帕金森病患者经历与健康对照组正常衰老过程不同的加速脑萎缩，表现为侧脑室扩大和靶向基底节结构的体积减少。这项研究的数据可能有助于更好地了解疾病的进展，或许还会将症状进展与结构MRI的变化以及对情绪、记忆和嗜睡的评估联系起来。计划筛查164人，目标是招募134名受试者(54名对照组和80名帕金森病患者)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a clinical study will test the hypothesis that PD patients experience accelerated brain atrophy distinct from the normal aging process in healthy controls as shown in lateral ventricular enlargement and volume loss in targeted basal ganglia structures. Data from this study might help to better understand the disease progression and perhaps correlate symptom progression with changes in structural MRI and evaluations of mood, memory and sleepiness. Plans are to screen 164 people with the goal of recruiting 134 subjects (54 controls and 80 PD patients).