NMR STUDIES OF LARGE PROTEIN COMPLEXES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目是关于研究大型蛋白质机械的结构和动力学性能的。更具体地说，我们将研究SecA马达ATPase(204 KDa)和SecB伴侣(70 KDa)，这是一般分泌(SEC)途径的两个重要组成部分。我们感兴趣的是了解这两种蛋白质在分泌过程中如何相互作用以及如何与其他配体相互作用

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project is about studying the structural and dynamic properties of large protein machinaries. More specifically, we will study the SecA motor ATPase (204 kDa) and the SecB chaperone (70 kDa), two vital components of the general secretion (Sec) pathway. We are interested in understanding how the two proteins interact with each other and with other ligands during the secretion proc