Methodology Core

核心单位人员将参与提供以下四项主要服务：项目 设计、统计支持、弗雷明翰/北京/社会变革管理计划和审调处流行病学分析和管理。 虽然这些服务可以单独考虑以便于呈现，但它们实际上代表了丰富的 综合功能网络将在多个方面促进MCRC的性能。首先， 这些服务的集中化有助于整合该中心的多个研究项目，并将 为他们的管理提供便利。第二，核心服务职能将提供补充支持 通过MCRC提案资助的流行病学和其他临床研究项目，以及 正在或将从其他来源获得资金的其他项目的数量。这个核心单位已经提供了 为多个外部资助项目(例如目前的四个R-OL/U-01‘S)提供大量研究支持，并将 在下一个5年周期中继续这样做。RESCU还将为新的 在赠款周期内演变的项目。第三，核心将为其他研究活动提供服务 在关节炎中心，包括基础和临床研究项目，如脉管炎和 硬皮病。第四，核心基金将使我们的工作人员能够继续为研究人员提供咨询支持 其他关节炎单位。 核心单位安排将建立一个扩展工作人员职能的资源网络 除了具体的项目任务外，还有助于有效地利用工作人员的时间。的两个主要功能 这一中心资源是该支助单位成员共享的办公空间，使他们能够 频繁的互动，以及每周的员工会议，在会上正在进行的和拟议的研究项目 经过严格的评估。因此，这一成功核心单位的延续将提供一套集中和 共享资源，这将提高我们在一个特别强调中心的领域的生产力，这将 为其他需要设计和分析建议的关节炎研究人员提供资源支持。这 核心单位的外部支持职能将有助于实现NIH中心的主要目标之一 程序。

Core unit personnel will be involved in providing each of the following four major services: project design, statistical support, Framingham/Beijing/MOST and OAI epidemiologic analyses and administration. Although these services can be considered separately for ease of presentation, they in fact represent a rich network of integrated functions that will contribute to MCRC performance in a number of ways. First, the centralization of these services helps to integrate the multiple research projects of the Center and will also serve to facilitate their administration. Second, the core service functions will provide supplemental support for projects in epidemiology and other clinical research funded through this MCRC proposal and for a number of other projects that are or will be funded from other sources. This core unit already provides substantial research support for multiple externally funded projects (e.g. four current R-Ol/U-01's) and will continue to do so during the next 5 year cycle. RESCU will also provide critical start up support for new projects that evolve during the grant cycle. Third, the core will provide services to other research activities in the Arthritis Center including basic and clinical research projects such as those in vasculitis and scleroderma. Fourth, core funds will enable our staff to continue their consultative support of researchers at other arthritis units. The core unit arrangement will create a network of resources that extends the functions of staff beyond their specific project assignments and facilitates the efficient use of staff time. Two key features of this central resource are the shared office space of members of this support unit which leads them to frequent interactions, and the weekly staff meetings in which ongoing and proposed research projects are critically evaluated. The continuation of this successful core unit will thus provide a set of centralized and shared resources that will enhance our productivity in an area of special Center emphasis and that will contribute to a resource in support of other arthritis investigators who need design and analysis advice. This external support function of the core unit will help to achieve one of the major goals of the NIH Centers Program.