ROLE OF GALANIN-EXPRESSING LEPTIN RECEPTOR NEURONS IN LEPTIN ACTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项题为“下丘脑背内侧核和弓状核内甘丙素/瘦素受体神经元在瘦素作用中的作用”的提议旨在研究在下丘脑背内侧核(DMH)和弓状核(ARC)内发现的一类新的甘丙素和瘦素受体表达神经元(GAL/LepRb神经元)。瘦素激素已被发现对人类和啮齿动物在能量平衡的中央调节中起着关键作用。在这里，瘦素作用于其受体(LepRb)来调节 然而，单个中央瘦素受体表达位点对瘦素作用的重要性在很大程度上是未知的。新发现的Gal/LepRb神经元群体与ARC中其他已知的LepRb群体不同，拟议研究的总体目标是了解它们在调节食物消耗和能量平衡方面的综合作用

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal entitled "Role of galanin/leptin receptor neurons within the dorsomedial hypothalamus and arcuate nucleus in leptin action" aims to investigate a novel population of galanin and leptin receptor expressing neurons (gal/LepRb neurons) found within the dorsomedial hypothalamus (DMH) and the arcuate nucleus (ARC). The hormone leptin has been found to be crucial for humans and rodents in the central regulation of energy homeostasis. Here, leptin acts on its receptor (LepRb) to regulate feeding circuits and energy expenditure, however, the importance of individual central leptin receptor expressing sites for leptin action is largely unknown. The newly identified population of gal/LepRb neurons is distinct from other known LepRb populations in the ARC and the overall objective of the proposed studies is to understand their integrated role in regulating food consumption and energy homeostasis