Identification of Biomarkers for Response to Chemoprevention of Colon Cancer

对遗传性肥胖小鼠的新干预研究采用了豆类饮食，测试了暴露于偶氮甲烷后对结肠癌的缓解作用。在最近完成的息肉预防试验中，以豆类为基础的饮食被选择来模拟条件，在该试验中，食用最高四分之一豆类(海军、利马、肾脏、黑色等)的人类受试者显示，晚期腺瘤的发生率降低了3倍(E.Lanza及其同事，2006,2009)。整个豆类和两种豆类成分在降低肿瘤多样性方面显示出有效性(Bobe等人，Nutr CA，2008年)。最近的研究已经确定与炎症相关的细胞因子是豆类饮食有效性的指标(Mentor-Marcel等人，2009年)。目前的研究目的是在有效条件下确定豆类饮食的重要分子靶标以及预测生物标记物。粪便结肠癌细胞的基因表达谱揭示了2到3组基因的变化表明其风险(赵等人，CA Prev res，2009)。

New intervention studies in genetically obese mice employ a bean-based diet being tested for attenuation of colon carcinogenesis following exposure to azoxymethane. The bean-based diet was chosen to mimic conditions in the recently completed polyp prevention trial in which human subjects consuming the highest quartile of beans (navy, lima, kidney, black etc) showed a 3-fold reduction in ocurrence of advanced adenoma (E. Lanza and coworkers 2006, 2009). The whole beans and two bean fractions showed efficacy in attenuating tumor multiplicity (Bobe et al, Nutr Ca 2008). Recent studies have identified inflammation-associated cytokines as indicators of bean-diet efficacy (Mentor-Marcel et al Ca Prev Res 2009). Current studies are aimed at identifying funtionally significant molecular targets of the bean diets under conditions of efficacy as well as predictive biomarkers. Gene expression profiling of fecal colonocytes has revealed sets of 2 to 3 genes whose changes are indicative of risk (Zhao et al Ca Prev Res 2009).