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Genes associated with endocrine tumorigenesis

Genes associated with endocrine tumorigenesis
与内分泌肿瘤发生相关的基因
批准号：
7967843
负责人：
Sunita Agarwal
金额：
$92.71万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7967843
关键词：
AchievementCDK6-associated protein p18CDKN2A geneCandidate Disease GeneCategoriesCell Cycle ProgressionCell ProliferationCellsCyclin-Dependent Kinase InhibitorEmbryonic DevelopmentEndocrineEndocrine Gland NeoplasmsEventFamilyGenesGerm-Line MutationGoalsHistocompatibility TestingHomeostasisInheritedIslet Cell TumorIslets of LangerhansLifeMeninMolecularMolecular GeneticsMultiple Endocrine Neoplasia Type 1NeoplasmsRegulationRegulator GenesSyndromebasecell transformationinsightinterestmouse modelpositional cloningprotein protein interactiontumortumorigenesis

项目摘要

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相关文献

中文摘要
翻译
由MEN 1基因编码的menin的功能失活导致遗传性多发性内分泌肿瘤1型（MEN 1）综合征和一些但不是全部的散发性胰腺内分泌肿瘤。 因此，探索menin上游或下游的分子事件可能指向负责此类肿瘤类型的其他致病基因和/或调控事件。我们目前的努力是针对研究2类基因的脑膜炎调节的转录，转录后，蛋白质：蛋白质相互作用，和亚细胞定位事件：1）细胞周期蛋白依赖性激酶抑制剂，和2）内分泌胰腺分化因子。
英文摘要
Functional inactivation of menin, encoded by the MEN1 gene, causes the inherited multiple endocrine neoplasia type 1 (MEN1) syndrome and some but not all sporadic pancreatic endocrine tumors. Therefore exploring molecular events upstream or downstream of menin could point to other causative genes and/or regulatory events responsible for such tumor types. Our current efforts are directed towards studying 2 categories of genes for menin-regulated transcriptional, post-transcriptional, protein:protein interaction, and sub-cellular localization events: 1) Cyclin-dependent kinase inhibitors, and 2) Endocrine pancreas differentiation factors.
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