High Throughput, Label-Fee Molecular Interaction Platform for Membrane Protein Ta

描述(由申请人提供)：我们的计划将创建一种新的高通量(HT)筛选工具，以满足位于细胞膜内的有价值的药物靶点研究中未得到满足的需求。我们打算创造新的表面化学、样品制备协议、系统软件和机器人技术，这些技术将与我们的专利分子相互作用检测技术--背向散射干涉测量技术相结合。我们将通过分析商业上可用的细胞膜蛋白系统及其天然相互作用分子来证明该平台的价值。一旦建成，我们新的HT筛查平台有望为有价值的治疗和诊断技术的发展做出贡献，对医疗保健产生显著的积极影响。 公共卫生相关性：针对细胞膜靶标的药物构成了最重要的治疗学和重点药物研究类别之一。可用于支持这项研究的工具缺乏支持能力，是取得进展的障碍。我们的计划将创建一个新的研究平台，对推进膜靶向药物研究的进展产生重大而强大的影响，产生新的和改进的疗法，将对疾病的治疗产生积极影响，改善医疗保健，同时降低其成本。

DESCRIPTION (provided by applicant): Our program will create a novel high throughput (HT) screening tool to address unmet needs in the research of valuable drug targets that are located within cell membranes. We intend to create novel surface chemistries, sample preparation protocols, system software, and robotics that will be combined with our proprietary molecular interaction detection technology known as Back-scattering Interferometry. We will demonstrate the value of this platform by analyzing a commercially available cell membrane protein system and its natural interacting molecule. Once completed, our new HT screening platform is envisioned to contribute to the development of valuable therapeutics and diagnostics, making a significantly positive impact upon healthcare. PUBLIC HEALTH RELEVANCE: Drugs directed against cell membrane targets comprise one of the most important classes of therapeutics and focused pharmaceutical research. Tools available to support this research lack enabling capabilities, and are a barrier to progress. Our program will result in the creation of a novel research platform that will exert a substantial and powerful impact to advance progress in membrane target drug research, yielding new and improved therapeutics that will positively impact the treatment of disease, improving healthcare while reducing its cost.