Tim Upgrade for Nonhuman-Primate-Dedicated Magnetom Trio

描述（由申请人提供：俄勒冈州国家灵长类动物研究中心（ONPRC）保持一个独立的，2,500平方米。英尺磁共振成像（MRI）设施，是在100英尺。ONPRC手术空间的一部分，并致力于非人类灵长类动物受试者的研究。这种安排使基于MRI的调查能够与ONPRC的几乎任何正在进行的研究项目相结合。ONPRC MRI设施的技术监督由俄勒冈州健康与科学大学（OHSU）高级成像研究中心（AIRC）提供。通过这种合作奋进，一些非人类灵长类动物的MRI研究导致了几种新的成像策略的发展，用于监测灵长类动物病理和发育的生理和解剖过程。这些实验中的每一个都对当前的临床研究具有潜在的直接转化价值。在授予合同时，ONPRC Siemens WITHTOM 3 T Trio MRI系统将有7年的历史。由于仪器在长期使用中的疲劳，系统故障变得越来越频繁，并且由于制造商对这种老式机器的更换零件库存较少，维修时间也越来越短。在这项申请中，正在申请资金，用于对ONPRC MRI系统进行“总成像矩阵”（Tim）升级。在执行多个接收器通道的同时采集的能力方面的若干最新技术发展已经刺激MRI系统制造商实质上修改硬件设计。目前的MRI系统与ONPRC系统的不同之处在于拥有更广泛的“并行成像”能力。它们可以集成更多的信号输入通道，并应用改进的数据处理算法来合成图像。此外，梯度线圈设计的改进使得能够在动态实验中更快速地获取图像，并且还改进了水扩散的测量-这是一种用于在微观水平上表征组织结构的强大方法。在ONPRC/AIRC安排的背景下，MRI系统的升级将通过实现非人类灵长类动物MRI系统和位于OHSU主校区（10英里以东）的AIRC人类Tim MRI系统之间的协议共享，极大地促进转化研究。ONPRC校园）。目前，由于Tim和非Tim仪器的软件和硬件配置的固有不兼容性，OHSU和其他研究机构系统开发的图像采集和处理程序无法在系统之间共享。因此，大多数技术研究和开发都是在时间生成系统的框架内进行的。申请的资金将有助于实现ONPRC MRI系统的全部转化潜力。 公共卫生相关性：要求提供资金用于升级位于俄勒冈州国家灵长类动物研究中心（ONPRC）校园内的MRI系统，该系统专门用于非人类灵长类动物研究主题的研究。大多数非人类灵长类动物的研究集中在医学知识的发展，可用于指导未来的临床实践。要求的升级将为ONPRC MRI系统配备改进的硬件和软件系统，使其上执行的测量与用于检查人类受试者的MRI系统上执行的测量相同。

DESCRIPTION (provided by applicant: The Oregon National Primate Research Center (ONPRC) maintains a free-standing, 2,500 sq. ft. magnetic resonance imaging (MRI) facility that is within 100 ft. of the ONPRC surgical space, and is dedicated to the study of nonhuman primate subjects. This arrangement enables MRI-based investigations to be interfaced with virtually any ongoing research project at the ONPRC. Technical oversight of the ONPRC MRI facility is provided by the Oregon Health & Science University (OHSU) Advanced Imaging Research Center (AIRC). Through this cooperative endeavor, a number of nonhuman-primate-based MRI investigations are leading to the development of several new imaging strategies for monitoring physiological and anatomical processes that underlie primate pathology and development. Each of these experiments is potentially of direct translational value to current clinical research. At the time of award, the ONPRC Siemens MAGNETOM 3T Trio MRI system will be seven years old. Due to instrumentation fatigue over long-term use, system failures are becoming more frequent, and repair times are lengthier due to the manufacturer's smaller inventory of replacement parts for machines of this vintage. In this application, funds are being requested for a "Total imaging matrix" (Tim) upgrade to the ONPRC MRI system. Several recent technological developments in the ability to perform simultaneous acquisition of multiple receiver channels have stimulated MRI system manufacturers to substantially modify hardware designs. Current MRI systems differ from the ONPRC system by possessing more extensive "parallel imaging" capabilities. They can integrate a larger number signal input channels, and apply improved data processing algorithms to synthesize images. Additionally, improvements in gradient coil design have lead to the ability to more rapidly acquire images in dynamic experiments, and additionally improve measurements of water diffusion - a powerful methodology for characterizing tissue structure on the microscopic level. Within the context of the ONPRC/AIRC arrangement, an upgrade of the MRI system will greatly facilitate translational research by enabling sharing of protocols between the nonhuman primate MRI system and the AIRC's human Tim MRI systems located on the OHSU main campus (10 miles east of the ONPRC campus). Currently, image acquisition and processing procedures developed at OHSU and other research institutions system cannot be shared between systems due to inherent incompatibilities in software and hardware configurations of Tim and non-Tim instruments. As a result, most technological research and development occurs within the framework of Tim-generation systems. The requested funds will facilitate realization of the full translational potential of the ONPRC MRI system. PUBLIC HEALTH RELEVANCE: Funds are requested for the upgrade of an MRI system that is located on the Oregon National Primate Research Center (ONPRC) campus, and is dedicated to the study of nonhuman primate research subjects. Most nonhuman primate research focuses on the development of medical knowledge that can be used to direct future clinical practice. The requested upgrade will equip the ONPRC MRI system with improved hardware and software systems that will enable measurements performed on it to be identical to those performed on MRI systems used to examine human subjects.