Echocardiograph and Vascular Doppler

描述（由申请人提供）：人体临床研究依赖于对受试者心血管解剖和生理的准确评估。公众的健康取决于医学科学能否找到治疗心脏病的方法，心脏病是美国男性和女性的头号杀手，能否治愈和预防癌症，能否预防和管理糖尿病，能否预防肥胖。影响健康的研究干预措施，如饮食、运动、药物和设备，通过测量心脏和血管功能的设备进行评估。超声心动图和血管多普勒是临床研究中用于评估受试者生理基线特征及其对临床研究干预反应的评估工具。超声心动图是一种测量心脏结构和功能的方法。血管多普勒是对血管结构和功能的测量。超声心动图和血管多普勒超声是一种评估心脏和血管功能和结构的研究和临床方法。我们正在申请一台Philips iE33超声心动图，带有血管多普勒探头和分析软件，以支持NCRR/CTSA资助的临床研究中心的临床研究项目。设备费用为206 760美元。该共享设备将通过临床研究中心进行管理，并可供约560个正在进行的研究方案和未来在该中心进行的研究方案使用。

DESCRIPTION (provided by applicant): Clinical research in humans is dependent on an accurate assessment of the subjects' cardiovascular anatomy and physiology. The health of the public is dependent on medical science finding cures for heart disease, the number one killer of men and women in the US, cures and prevention of cancer, prevention and management of diabetes and prevention of obesity. Research interventions that affect health such as diet, exercise, medications and devices are evaluated by equipment that measures heart and blood vessel function. Echocardiography and vascular Doppler are assessment tools used in clinical research to evaluate the baseline characteristics of subjects' physiology and their response to clinical research interventions. Echocardiography is a measurement of heart structure and function. Vascular Doppler is a measurement of blood vessel structure and function. A research and clinical method of assessing the function and structure of the heart and blood vessels is through echocardiography and vascular Doppler using sound waves. We are requesting a Philips iE33 Echocardiograph with a Vascular Doppler probe and analysis software to support the clinical research program in the NCRR/CTSA--funded Clinical Research Center. The cost of the equipment is $206,760. This shared equipment will be administered through the Clinical Research Center and available for use by the ~560 active research protocols and future research protocols conducted on the Center. PUBLIC HEALTH RELEVANCE: An accurate assessment of human anatomy and physiology is critical to the success of clinical research. Echocardiography and vascular Doppler are assessment tools used in clinical research to evaluate the baseline characteristics of subjects' physiology and their response to clinical research interventions. This proposal requests financial support to purchase a Philips iE33 echocardiograph with a vascular Doppler probe and analysis software to be shared among clinical investigators who are seeking therapies for the diseases that are affecting the health of the nation.